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Antioxidative 2H-chromenyls attenuate pro-inflammatory 5-lipoxygenase and carbolytic enzymes: Prospective bioactive agents from Babylonidae gastropod mollusk Babylonia spirata

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Relation http://eprints.cmfri.org.in/14297/
https://onlinelibrary.wiley.com/doi/abs/10.1111/jfbc.13196
DOI: 10.1111/jfbc.13196
 
Title Antioxidative 2H-chromenyls attenuate pro-inflammatory
5-lipoxygenase and carbolytic enzymes: Prospective bioactive
agents from Babylonidae gastropod mollusk Babylonia spirata
 
Creator Chakraborty, Kajal
Salas, Soumya
 
Subject Bioprospecting
Bioactive compounds
Gastropods
 
Description Oxygenated heterocycles are emerging as valuable pharmacophores involved in the
prophylaxis and treatment of several diseases elicited by the reactive oxygen species.
Bioassay-led chromatographic fractionation of the organic extract of the gastropod
mollusk Babylonia spirata (family Babylonidae) yielded two unprecedented
2H-chromenyl derivatives characterized as 2-(butyryloxy)-5-hydroxy-hexahydro-2Hchromene-
3-methyl carboxylate (1) and (3-hydroxy-hexahydro-2H-chromen-2-yl)
methyl pentanoate (2). The chromenyl derivative (1) registered significantly greater
attenuation potential against pro-inflammatory 5-lipoxygenase (IC50 ~ 2.02 mM) than
those exhibited by the compound (2) (IC50 2.76 mM) and the non-steroidal anti-inflammatory
drug ibuprofen (IC50 4.36 mM, p < .05). The compound (1) exhibited comparable
antioxidant activity (IC50 1.47–1.72 mM) with standard antioxidative agent
α-tocopherol (IC50 1.4–1.7 mM). Inhibitory potential of chromenyl derivative (1) toward
α-glucosidase (IC50 1.18 mM) and α-amylase (IC50 0.92 mM) was greater than
those displayed by 2 (IC50 1.16–1.56 mM). Structure–activity relationships revealed
that bioactivities of the compounds were determined by the electronic factors and
hydrophilic–lipophilic balance.
 
Date 2020
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/14297/1/Journal%20of%20Food%20Biochemistry_2020_Kajal%20Chakraborty_Antioxidative2H-chromenyls%20attenuate%20pro-inflammatory%205-lipoxygenase%20and%20carbolytic%20enzymes.pdf
Chakraborty, Kajal and Salas, Soumya (2020) Antioxidative 2H-chromenyls attenuate pro-inflammatory 5-lipoxygenase and carbolytic enzymes: Prospective bioactive agents from Babylonidae gastropod mollusk Babylonia spirata. Journal of Food Biochemistry, 44 (6). pp. 1-11. ISSN 1745–4514