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Sulfated N-acetylglucosamino-glucuronopyranosyl-arabinopyranan from seafood Amphioctopus neglectus attenuates angiotensin-II prompted cardiac hypertrophy

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Relation http://eprints.cmfri.org.in/14393/
https://www.sciencedirect.com/science/article/pii/S0141813020337818?via%3Dihub
https://doi.org/10.1016/j.ijbiomac.2020.07.037
 
Title Sulfated N-acetylglucosamino-glucuronopyranosyl-arabinopyranan
from seafood Amphioctopus neglectus attenuates angiotensin-II
prompted cardiac hypertrophy
 
Creator Chakraborty, Kajal
Krishnan, Soumya
Joy, Minju
 
Subject Bioprospecting
Bioactive compounds
Biochemistry
 
Description Angiotensin converting enzyme (ACE) is amultifunctional enzymeinvolved in translation of angiotensin-I (AngI)
to vasoconstrictor angiotensin-II (AngII). A sulfated N-acetylglucosamino-glucuronopyranosyl-arabinopyranan
characterized as poly-[(2-methoxy-β-arabinopyranosyl)-(1 → 3)-(β-glucurono)-(1 → 4)-(2-acetamido-2-
deoxy-3,6-di-O-sulfonato-β-glucopyranose)] was purified and reported first time from the edible portion of
Amphioctopus neglectus and evaluated for various pharmacological properties. The polysaccharide exhibited
potential ACE attenuation property (IC50 0.11 mg mL−1), whereas molecular docking simulations displayed its
efficient binding at the ACE active site with lesser inhibitory constant (Ki) of 17.36 nM and binding energy
(−10.59 kcal mol−1). The in-vitro analysis showed that the studied polysacharide attenuated AngII prompted
cardiac hypertrophy at 50 μg mL−1 in the cardiomyoblast cells, whereas 48% reduction in cellular surface area
with extended viability could be correlated with anti-hypertrophic properties of the studied polysaccharide.
The sulfated N-acetylglucosamino-glucuronopyranosyl-arabinopyranan purified fromA. neglectus could function
as a prospective functional lead against the pathophysiological conditions leading to hypertension.
 
Date 2020
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/14393/1/International%20Journal%20of%20Biological%20Macromolecules_2020_Kajal%20Chakraborty_Sulfated%20N-acetylglucosamino-glucuronopyranosyl-arabinopyranan.pdf
Chakraborty, Kajal and Krishnan, Soumya and Joy, Minju (2020) Sulfated N-acetylglucosamino-glucuronopyranosyl-arabinopyranan from seafood Amphioctopus neglectus attenuates angiotensin-II prompted cardiac hypertrophy. International Journal of Biological Macromolecules, 163. pp. 1223-1232.