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<p>Anti-VEGFR-2 Kinase Effects of Cyclo (<em>N<sup>α</sup></em>-dinicotinoyl)-bis-[(L-valinyl)- L-lysine] and its Anticancer Activities Against Different Cancer Cell Lines</p>

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Title Statement <p>Anti-VEGFR-2 Kinase Effects of Cyclo (<em>N<sup>α</sup></em>-dinicotinoyl)-bis-[(L-valinyl)- L-lysine] and its Anticancer Activities Against Different Cancer Cell Lines</p>
 
Added Entry - Uncontrolled Name Amr, A E; Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC), King Saud University, Riyadh 11 451, Saudi Arabia
Elsayed, E A; Bioproducts Research Chair, Zoology Department, College of Science, King Saud University, Riyadh 11 451, Kingdom of Saudi Arabia
Al-Omar, M A; Pharmaceutical Chemistry Department, College of Pharmacy, Drug Exploration & Development Chair (DEDC), King Saud University, Riyadh 11 451, Saudi Arabia
El-Enshasy, H A; Institute of Bioproduct Development, Universiti Teknologi, Malasiya 81 310, skudai Johor, Malasiya
 
Uncontrolled Index Term Cyclic tripeptides; Pyridine derivatives; Anticancer; Animal model; Inhibition of VEGFR-2 tyrosine kinase
 
Summary, etc. <p>The current work aimed at preparing a cyclo (<em>N<sup>α</sup></em>-dinicotinoyl)-bis-[(L-valinyl)-L-lysine] from previously established synthetic routs. The derivative was investigated for its potential anticancer activities as well as its possible mechanism of action. The prepared compound showed variable anticancer activities against all tested cell lines. Furthermore, it showed very promising activities in terms of obtained IC50 values compared to known used drugs. The mechanism of action studies showed that the prepared tripeptide may act on cancerous cells through its inhibitory action on tyrosine kinase pathway. Animal model experiments proved the potential of the synthesized tripeptide as an anticancer agent against PC3 cancer cells.<em></em></p>
 
Publication, Distribution, Etc. Journal of Scientific and Industrial Research (JSIR)
2020-07-29 12:49:53
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/JSIR/article/view/38380
 
Data Source Entry Journal of Scientific and Industrial Research (JSIR); ##issue.vol## 79, ##issue.no## 05
 
Language Note en