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<p style="text-align: justify;"><span style="font-family: times new roman, times; font-size: small;">Phytochemical screening, anti-oxidant and anti-inflammatory activities of ethyl acetate extract of <em>Combretum punctatum</em> var. <em>squamosum</em></span></p>
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dc |
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| Title Statement |
<p style="text-align: justify;"><span style="font-family: times new roman, times; font-size: small;">Phytochemical screening, anti-oxidant and anti-inflammatory activities of ethyl acetate extract of <em>Combretum punctatum</em> var. <em>squamosum</em></span></p> |
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| Added Entry - Uncontrolled Name |
Thanzami, K ; Department of Pharmacy, Regional Institute of Paramedical & Nursing Sciences (RIPANS), Aizawl 796017, Mizoram, India Pachuau, V L Thatpuii; Regional Institute of Paramedical and Nursing Sciences (RIPANS) Lalremruati, C ; DBT's Institutional Biotech Hub, RIPANS Kakoti, Bibhuti B; Dibrugarh University IBThub, RIPANS (funded by Dept of Biotchnology, GoI) |
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| Uncontrolled Index Term |
Utilization of ethnomedicinal plants; pharmacological activities Anti-inflammatory; Anti-oxidant; Ethnomedicine; Leihruisen; Phytoconstituents. |
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| Summary, etc. |
<p style="text-align: justify;">The objective of this study was to carry out the phytochemical screening of the ethyl acetate extract of <em>Combretum punctatum </em>var. <em>squamosum </em>and to investigate anti-inflammatory and anti-oxidant activities. The phytochemical investigation indicated the presence of flavonoids and steroids in the extract. Anti-inflammatory activity was studied by <em>in vitro </em>inhibition of albumin denaturation and HRBC membrane stabilization methods; <em>in vivo </em>cotton pellet induced granuloma and carrageenan-induced paw oedema studies. The anti-oxidant activity was studied by lipid peroxidation and DPPH radical scavenging activity assays.The ethyl acetate extract at different concentrations showed a significant percent inhibition of albumin denaturation and percent inhibition of haemolysis when compared with the standard. The extract at 200 and 400 mg/kg b.w. significantly reduced cotton pellet granuloma (<em>P </em><0.001) and carrageenan paw oedema (<em>P </em><0.05) when compared with the standard in rats.The extract at different concentrations also showed a significant percent inhibition of lipid peroxidation and DPPH when compared with the standard.Thus, the result indicates that the ethyl acetate extract exhibited significantly good anti-inflammatory and anti-oxidant activities.</p> |
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| Publication, Distribution, Etc. |
Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] 2020-08-07 14:42:12 |
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| Electronic Location and Access |
application/pdf http://op.niscair.res.in/index.php/IJNPR/article/view/24838 |
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| Data Source Entry |
Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 11, ##issue.no## 1 (2020): March 2020 |
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| Language Note |
en |
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