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<p style="text-align: justify;">Antidiabetic activity of <em>Carallia brachiata</em> Lour. leaves hydro-alcoholic extract (HAE) with antioxidant potential in diabetic rats</p>

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Title Statement <p style="text-align: justify;">Antidiabetic activity of <em>Carallia brachiata</em> Lour. leaves hydro-alcoholic extract (HAE) with antioxidant potential in diabetic rats</p>
 
Added Entry - Uncontrolled Name Junejo, Julfikar Ali; Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh 786004, Assam, India
Rudrapal, Mithun ; Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh 786004, Assam, India
Zaman, Kamaruz ; Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh 786004, Assam, India
(UGC), New Delhi
 
Uncontrolled Index Term Antidiabetic activity; Antioxidant activity; Carallia brachiata; Hydro-alcoholic extract; Plant flavonoids.
 
Summary, etc. <p style="text-align: justify;">Ethnomedicinal surveys have documented the traditional use of <em>Carallia brachiata </em>(Lour.) Merill (Rhizophoraceae) leaves in the management of diabetes mellitus in the Northeastern region of India. This study screens the hydro-alcoholic extract (HAE) of <em>C. brachiata </em>leaves for antioxidant and antidiabetic activities. The HAE was prepared using ethanol:water (7:3) by cold maceration method. The antidiabetic activity of HAE was evaluated <em>in vivo </em>in streptozotocin-induced diabetic rats at the doses of 250 or 500 mg/kg body weight for 21 days. The extract was also evaluated for <em>in vitro </em>and <em>in vivo </em>antioxidant activity. Results revealed that HAE of <em>C. brachiata </em>leaves possesses good hypoglycemic activity in diabetic rats. The hypoglycemic activity of HAE was found significant as compared to normal rats. Results of antioxidant activity were found statistically significant compared to standard drugs, quercetin and gallic acid. Results indicated a possible role of the HAE of <em>C. brachiata </em>leaves as herbal antioxidants in the prevention and/ or treatment of oxidative stress-induced diabetes. Results suggested that antioxidant plant phenolics/ flavonoids might be responsible for the antidiabetic efficacy of HAE. Further research can be undertaken on the HAE of <em>C. brachiata </em>leaves for exploration of biochemical mechanisms of antidiabetic action with the isolation of bioactive flavonoids having antidiabetic potential.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2020-08-07 14:42:12
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/24717
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 11, ##issue.no## 1 (2020): March 2020
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/24717/465477167
http://op.niscair.res.in/index.php/IJNPR/article/download/24717/465477168
 
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