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<p style="text-align: justify;">Comparison of antinociceptive and antioxidative effects of Tualang honey and Vitamin C in a rat model of inflammatory pain</p>

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Title Statement <p style="text-align: justify;">Comparison of antinociceptive and antioxidative effects of Tualang honey and Vitamin C in a rat model of inflammatory pain</p>
 
Added Entry - Uncontrolled Name Hasim, Hidani ; Department of Physiology, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
Ahmad Suhaimi, Siti Qusyasyiah ; Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
Abd Aziz, Che Badariah ; Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
Wei Yaw, Tam ; Department of Anesthesiology School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
Hassan, Shamsul Kamalrujan ; Department of Anesthesiology School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia
USM Short Term Grant (304/PPSP/61313092)
 
Uncontrolled Index Term Antioxidant; Inflammatory pain; Oxidative stress; Tualang honey; Vitamin C.
 
Summary, etc. <p style="text-align: justify;">This study aimed to compare the antinociceptive and antioxidative effects of Tualang honey and Vitamin C in formalininduced pain in the rat. About 24 Sprague Dawley male rats were randomized into three groups and each group (n=6) received either distilled water (C) or Tualang honey (1.2 g/kg body weight/day) (TH) or Vitamin C (20 mg/kg body weight/day) (VC) for 10 consecutive days. On the tenth day, intraplantar formalin 1% (0.1 mL) was given one hour after the treatment. Rat’s pain behaviour was recorded using a digital camera for an hour. The rats were sacrificed two hours postformalin injection and blood was taken to measure the malondialdehyde (MDA) level, catalase (CAT) and superoxide dismutase (SOD) activities. TH not VC significantly reduced the pain behavior score and improved oxidative stress parameters compared to control. However, MDA level was not significantly different between groups. Interestingly, there was a good inverse correlation between CAT level and mean pain behavior score suggesting the important role of antioxidants in modulating the inflammatory pain responses. In conclusion, TH has better antinociceptive and antioxidative properties compared to VC. The antinociceptive property of TH might be partly contributed by increasing CAT level in this model of inflammatory pain.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2020-08-07 14:42:12
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/24665
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 11, ##issue.no## 1 (2020): March 2020
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/24665/465477037
http://op.niscair.res.in/index.php/IJNPR/article/download/24665/465477038
http://op.niscair.res.in/index.php/IJNPR/article/download/24665/465477039
http://op.niscair.res.in/index.php/IJNPR/article/download/24665/465477040
http://op.niscair.res.in/index.php/IJNPR/article/download/24665/465477151
 
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