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Genomics approaches to synthesis plant-based biomolecules for therapeutic applications to combat SARS-CoV-2

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Title Genomics approaches to synthesis plant-based biomolecules for therapeutic applications to combat SARS-CoV-2
 
Creator Sharma, Namisha
Muthamilarasan, Mehanathan
Prasad, Ashish
Prasad, Manoj
 
Subject SARS-CoV-2
Coronavirus
Genomics
Genetic manipulation
Therapeutics
Plant-based drugs
covid19
 
Description Accepted date: 20 July 2020
COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
devastative to the humankind for which neither vaccines nor precise therapeutic molecules
for treatment are identified. The search for new drugs and repurposing of existing drugs are
being performed; however, at the same time, research on plants to identify novel therapeutic
compounds or testing the existing ones is progressing at a slower phase. In this context,
genomics and biotechnology offer various tools and strategies to manipulate plants for
producing those complex biopharmaceutical products. This review enumerates the scope for
research on plant-based molecules for their potential application in treating SARS-CoV-2
infection. Strategies to edit gene and genome, overexpression and silencing approaches,
and molecular breeding for producing target biomolecules in the plant system are discussed
in detail. Altogether, the present review provides a roadmap for expediting research on using
plants as a novel source of active biomolecules having therapeutic applications.
Authors’ work in this area is supported by J.C. Bose National Fellowship Grant of
Department of Science and Technology, Government of India (File No.: JCB/2018/000001).
N.S. acknowledges the SERB Women Excellence Award from Science and Engineering
Research Board, Govt. of India (File No. WEA/2020/000004). A.P. acknowledges the
Council for Scientific and Industrial Research, Govt. of India for research fellowship. Authors
are thankful to DBT-eLibrary Consortium (DeLCON) for providing access to e-resources.
 
Date 2020-07-29T09:37:26Z
2020-07-29T09:37:26Z
2020
 
Type Article
 
Identifier Genomics, 112(6): 4322-4331
0888-7543
https://www.sciencedirect.com/science/article/pii/S0888754320308958
https://doi.org/10.1016/j.ygeno.2020.07.033
http://223.31.159.10:8080/jspui/handle/123456789/1082
 
Language en_US
 
Format application/pdf
 
Publisher Elsevier B.V.