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<strong>Experimental studies in antisolvent crystallization: Effect of antisolvent ratio and mixing patterns</strong>

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Title Statement <strong>Experimental studies in antisolvent crystallization: Effect of antisolvent ratio and mixing patterns</strong>
 
Added Entry - Uncontrolled Name Waval, Aniket S; Department of Chemical Engineering, Institute of Chemical Technology
Patel, Pooja ; Department of Chemical Engineering, Institute of Chemical Technology
Nemade, Parag R; Department of Chemical Engineering, Institute of Chemical Technology
Mathpati, Channamallikarjun S; Department of Chemical Engineering, Institute of Chemical Technology
Science & Engineering Research Board (SERB) (File No: EMR/2016/001563)
 
Uncontrolled Index Term Antisolvent crystallization; Agitator design; Ultrasound;Non-uniformity; Mixing patterns; Stirred tank
 
Summary, etc. The crystals size and distribution play an important role in drug properties which has a major impact on the performance e.g., stability, solubility and bioavailability. The crystal size distribution (CSD) depends on the hydrodynamics and local degree of supersaturation in the crystallizer. In this study, we have investigated the effects of various operating conditions (antisolvent ratio, power, agitator design) using different mixing techniques such as impellers and ultrasound on CSD and average crystal size (ACS). It is found that mixing plays a dominant role in CSD and ACS. The hydrofoil (axial flow impeller) provides a wide range of ACS (406 to 240 μm) at lower power as compared to Rushton turbine (radial flow impeller) (395 to 375 μm). The mixed flow impeller produces the intermediate crystal size (365 to 345 μm). The increase in the antisolvent ratio results in a decrease in ACS. The same results observed for the power input.
 
Publication, Distribution, Etc. Indian Journal of Chemical Technology (IJCT)
2020-08-21 12:30:09
 
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http://op.niscair.res.in/index.php/IJCT/article/view/24607
 
Data Source Entry Indian Journal of Chemical Technology (IJCT); ##issue.vol## 27, ##issue.no## 1 (2020): Indian Journal of Chemical Technology
 
Language Note en