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<strong>One-pot synthesis of coumarin derivatives via microwave assisted Pechmann reaction and biological activity of substituted coumarin derivatives</strong>

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Title Statement <strong>One-pot synthesis of coumarin derivatives via microwave assisted Pechmann reaction and biological activity of substituted coumarin derivatives</strong>
 
Added Entry - Uncontrolled Name Sharma, Dipak ; Maharaja Ranjit Singh College of Professional Sciences Indore (M.P.)
monga, paramjeet ; Suresh Gyan Vihar University jaipur
bhasin, Sheetal ; Maharaja Ranjit Singh College of Professional Sciences Indore (M.P.)
Dubey, Arti ; Viva College, Virar, M.S.
Nagar, Hariom ; Suresh Gyan Vihar University, Jaipur, Rajasthan, India
 
Uncontrolled Index Term Antimicrobial; Antifungal; Coumarins; One-pot Microwave irradiation; Oxalic acid;Pechmann condensation
 
Summary, etc. Pechmann reaction is mainly used for the synthesis of substituted coumarins as it can be executed with straight forward primary resources and gives coumarin derivatives with excellent yields. In the present work coumarin derivatives have been synthesized by condensation of β-ketoesters and substituted phenols under microwave irradiation in solvent free condition in which oxalic acid is used as catalyst. Oxalic acid is found to be a potential environment friendly catalyst for synthesis of coumarins. The new method of synthesis described here offers a number of advantages of being convenient, safe, gentle, shorter reaction time, high yield, and cleanness as compared to the conventional methods. The synthesized compounds have been systematically characterized by IR and MS analyses. All products are examined for antimicrobial activity against the Gram positive (<em>Staphylococcus aureus</em> and <em>Bacillus subtilis</em>) and Gram negative (<em>Escherichia coli</em> and<em> Salmonella typhi</em>) bacteria and antifungal activity against two fungal species (<em>Aspergillus sp. </em>and<em> Fusarium graminearum</em>). All the compounds inhibited the growth of bacteria as well as fungi.
 
Publication, Distribution, Etc. Indian Journal of Chemical Technology (IJCT)
2020-08-21 13:49:58
 
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http://op.niscair.res.in/index.php/IJCT/article/view/21023
 
Data Source Entry Indian Journal of Chemical Technology (IJCT); ##issue.vol## 27, ##issue.no## 2 (2020): Indian Journal of Chemical Technology
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCT/article/download/21023/465465473
http://op.niscair.res.in/index.php/IJCT/article/download/21023/465465474
http://op.niscair.res.in/index.php/IJCT/article/download/21023/465465475
http://op.niscair.res.in/index.php/IJCT/article/download/21023/465465476
http://op.niscair.res.in/index.php/IJCT/article/download/21023/465465477
http://op.niscair.res.in/index.php/IJCT/article/download/21023/465465478