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<strong>Investigation of adsorption of metronidazole on Chitosan - Halloysite nanocomposites and controlled release</strong>

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Title Statement <strong>Investigation of adsorption of metronidazole on Chitosan - Halloysite nanocomposites and controlled release</strong>
 
Added Entry - Uncontrolled Name Açıkel, Yeşim Sağ; Hacettepe University
 
Uncontrolled Index Term Adsorption; Chitosan-Halloysite nanocomposite; Drug carrier; Metronidazole;Sustained release
 
Summary, etc. A novel nanocomposite drug carrier composing from chitosan (CTN) and halloysite nanotubes (HNTs) has been developed. For this purpose, the metronidazole (MNZ) is chosen as a model drug. The characterization of synthesized nanocomposites is performed by FTIR, TGA, DSC, SEM, TEM, BET and particle size distribution analysis. MNZ is loaded to chitosan-halloysite (CTN-HNT) nanocomposites in two ways; by direct loading and adsorption method. The adsorption of MNZ on CTN-HNT nanocomposites have been investigated as a function of medium <em>p</em>H, mass ratio of CTN to halloysite (HNT), amount of nanocomposite and drug concentration. The fit of MNZ adsorption equilibrium on CTN-HNT nanocomposites to the Langmuir and Freundlich models was investigated. The adsorption kinetics of MNZ on nanocomposites have been evaluated using the pseudo-first order rate equation of Lagergren and the pseudo-second-order rate equation of Mc-Kay and Ho. The controlled release of MNZ from CTN-HNT nanocomposites has also been investigated.
 
Publication, Distribution, Etc. Indian Journal of Chemical Technology (IJCT)
2020-08-21 13:49:58
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJCT/article/view/23616
 
Data Source Entry Indian Journal of Chemical Technology (IJCT); ##issue.vol## 27, ##issue.no## 2 (2020): Indian Journal of Chemical Technology
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCT/article/download/23616/465473793