Record Details

First report of chromenyl derivatives from spineless marine cuttlefish Sepiella inermis: Prospective antihyperglycemic agents attenuate serine protease dipeptidyl peptidase‐IV

CMFRI Repository

View Archive Info
 
 
Field Value
 
Relation http://eprints.cmfri.org.in/13641/
https://onlinelibrary.wiley.com/doi/abs/10.1111/jfbc.12824
DOI: 10.1111/jfbc.12824
 
Title First report of chromenyl derivatives from spineless marine
cuttlefish Sepiella inermis: Prospective antihyperglycemic
agents attenuate serine protease dipeptidyl peptidase‐IV
 
Creator Krishnan, Soumya
Chakraborty, Kajal
Joy, Minju
 
Subject Bioactive compound
New record
Cephalopods
Fish Biotechnology
 
Description Spineless marine cuttlefish Sepiella inermis has been considered as a popular dietary
cephalopod species in Asian and Mediterranean coasts. Bioassay‐directed purification of organic extract of S. inermis ensued in the characterization of two chromenyl
derivatives. The studied compounds exhibited significantly greater antioxidant potencies (IC50 ≤ 0.5 mg/ml) when compared with α‐tocopherol. The substituted 1H‐
isochromenyloxy‐11‐hydroxyethyl pentanoate isoform (compound 1) efficiently
inhibited the carbolytic enzymes along with key regulator of insulin secretion dipeptidyl peptidase‐IV (IC50 0.16 mg/ml). The molecular docking simulations displayed
optimum binding affinity of the compound 1 (−10.01 kcal/mol) with dipeptidyl peptidase‐IV and lesser inhibition constant (Ki 46.41 nM), which along with its permissible
hydrophobic‐hydrophilic balance (log Pow ~ 2) appeared to play significant roles in its
greater antihyperglycemic activity compared to other studied chromenyl isoform.
The greater antioxidant and antidiabetic properties of compound 1 could be utilized
as an important natural lead against hyperglycemic‐related disorders.
 
Date 2019
 
Type Article
PeerReviewed
 
Format text
 
Language en
 
Identifier http://eprints.cmfri.org.in/13641/1/Journal%20of%20Food%20Biochemistry_2019_Kajal%20Chakraborty_Prospective%20anti-hyperglycemic%20agents%20attenuate%20serine%20protease%20dipeptidyl%20peptidase-IV.pdf
Krishnan, Soumya and Chakraborty, Kajal and Joy, Minju (2019) First report of chromenyl derivatives from spineless marine cuttlefish Sepiella inermis: Prospective antihyperglycemic agents attenuate serine protease dipeptidyl peptidase‐IV. Journal of Food Biochemistry, 43 (5). pp. 1-12.