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Structure and regulation of SWEET transporters in plants: An update

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Title Structure and regulation of SWEET transporters in plants: An update
 
Creator Anjali, Anjali
Fatima, Urooj
Manu, M.S.
Ramasamy, Sureshkumar
Senthil-Kumar, Muthappa
 
Subject Oligomerization
Post-translational modification
Phosphorylation
Sugar transporters
Sugar will eventually be exported transporters
 
Description Accepted date: 25 August 2020
Sugar will eventually be exported transporters (SWEETs), a novel family of sugar transporters found in both
eukaryotes and prokaryotes, facilitate sugar flux across the cell membrane. Although these transporters were first
discovered in plants, their homologs have been reported in different organisms. SWEETs have critical roles in
various developmental processes, including phloem loading, nectar secretion, and pathogen nutrition. The
structure of bacterial homologs, called SemiSWEETs, has been well studied thus far. Here, we provide an
overview of SWEET protein structure and dynamic function by analyzing the solved crystal structures and
predicted models that are available for a few SWEETs in a monocot plant (rice) and dicot plant (Arabidopsis
thaliana). Despite the advancement in structure-related studies, the regulation of SWEETs remains unknown. In
light of reported regulatory mechanisms of a few other sugar transporters, we propose the regulation of SWEETs
at the post-translational level. We then enumerate the potential post-translational modification sites in SWEETs
using computational tools. Overall, in this review, we critically analyze SWEET protein structure in plants to
predict the post-translational regulation of SWEETs. Such findings have a direct bearing on plant nutrition and
defense and targeting the regulation at these levels will be important in crop improvement.
The SWEET transporter project at MS-K’s lab was funded by NIPGR
core funding. UF acknowledges the DBT-SRF fellowship (DBT/2013/
NIPGR/68) and NIPGR-SRF fellowship. Anjali acknowledges the CSIR
fellowship (09/803(0168)/2019-EMR-I_367532).
 
Date 2020-09-07T09:34:33Z
2020-09-07T09:34:33Z
2020
 
Type Article
 
Identifier Plant Physiology and Biochemistry, 156: 1-6
0981-9428
https://doi.org/10.1016/j.plaphy.2020.08.043
https://www.sciencedirect.com/science/article/pii/S0981942820304253
http://223.31.159.10:8080/jspui/handle/123456789/1091
 
Language en_US
 
Format application/pdf
 
Publisher Elsevier B.V.