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<p style="text-align: justify;">Effect of <em>Solanum torvum</em> Swartz on diabetic neuropathy in alloxan-induced diabetic rats</p>

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Title Statement <p style="text-align: justify;">Effect of <em>Solanum torvum</em> Swartz on diabetic neuropathy in alloxan-induced diabetic rats</p>
 
Added Entry - Uncontrolled Name Mohan, Mahalaxmi ; MGV's Pharmacy college, Panchvati, Nashik
Belapurkar, Pooja ; MGV’s Pharmacy College, Panchavati, Nashik, Maharashtra 422 003, India
More, Sonal ; MGV’s Pharmacy College, Panchavati, Nashik, Maharashtra 422 003, India
Patil, Gaurav ; MGV’s Pharmacy College, Panchavati, Nashik, Maharashtra 422 003, India
Director, Orchid Scientific, Ambad, Nashik
 
Uncontrolled Index Term Alloxan monohydrate; Diabetic neuropathy; Metformin; Solanum torvum
 
Summary, etc. <p style="text-align: justify;"><em>Solanum torvum </em>Swartz is a well-known traditional herbal medicinal plant used in diabetes and diabetes-related complications. The objective of the study was to evaluate the effect of <em>S. torvum</em> on diabetic neuropathy in alloxan-induced diabetic rats. Diabetes was induced in Wistar rats by using a single intraperitoneal injection of alloxan monohydrate (150 mg/kg; i.p.). After confirmation of diabetes, rats received metformin (120 mg/kg, p.o.) and STME (30 and 100 mg/kg, p.o) for 5 weeks. Diabetic rats showed significant (<em>P</em> &lt;0.05) behavioural changes, increase in blood glucose levels, decrease in relative organ weight of pancreas, significant (<em>P</em> &lt;0.05) decrease in reduced glutathione (RGSH) and significant (<em>P</em> &lt;0.05) increase in TBARS levels. While STME (100 mg/kg) treated diabetic rats significantly (<em>P</em> &lt;0.05) reversed the above parameters as compared to diabetic rats. Treatment with STME (100 mg/kg) has also reversed histopathological changes as observed in diabetic control rats. The study suggests that methanolic extract of <em>S. torvum </em>ameliorates diabetic neuropathy in alloxan-induced diabetic rats.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2020-09-26 17:05:23
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/21920
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 11, ##issue.no## 2 (2020): June 2020
 
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