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Tetrandrine derivatives IVa-IVd: Structural analysis and their inhibition rate against protein tyrosine kinase, and HL60 & A549 cancer cell lines

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Title Tetrandrine derivatives IVa-IVd: Structural analysis and their inhibition rate against protein tyrosine kinase, and HL60 & A549 cancer cell lines
 
Creator Chen, Chen
Lu, Ye
 
Subject Anticancer
Bromination
CCK-8
FGFR1
PTKs
Suzuki reaction
Tetrandrine
 
Description 1354-1358
Four tetrandrine (TET) derivatives (IVa-IVd) have been synthesized by Suzuki reaction of boronic acid derivatives and 5-bromo-tetrandrine obtained by bromination using tetrandrine as the starting material. The structures are analyzed by 1H NMR, 13C NMR and ESI-MS. The inhibition activities of IVa-IVd against HL60 and A549 cancer cell lines have been investigated by CCK-8 assay. The compounds having significant (P
 
Date 2020-09-26T07:35:07Z
2020-09-26T07:35:07Z
2020-09
 
Type Article
 
Identifier 0975-0975(Online); 0376-4710(Print)
http://nopr.niscair.res.in/handle/123456789/55341
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Source IJC-A Vol.59A(09) [September 2020]