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Benzimidazolium picrate single crystal: Synthesis, growth, characterization and their biological activity

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Title Benzimidazolium picrate single crystal: Synthesis, growth, characterization and their biological activity
 
Creator Vadivelan, Ganesan
Gohulavani, Grahandurai
Saravanabhavan, Munusamy
Murugesan, Venkatesan
Sekar, Marimuthu
 
Subject Benzimidazolium picrate
Charge-transfer complex
2,2-Diphenyl-2-picryl-hydrazyl
 
Description 1305-1312
Knowledge on charge-transfer complexes of drugs is important to understand the drug-receptor binding mechanism. Here, we have been synthesized the organic charge transfer complex of Benzimidazolium picrate (BP) and confirmed its molecular structure and carbon skeleton by 1H and 13C NMR spectral analysis. Asymmetric unit of BP consists of one benzimidazolium cation and a monovalent anion of picric acid. Decomposition pattern and thermal stability BP have been investigated using TG/DTA analysis. The interaction of the compound with calf thymus DNA is investigated by electronic absorption spectroscopy which indicates that the compound could interact with DNA through intercalation. The CT complex demonstrated significant free radical scavenging with 2,2-diphenyl-2-picryl-hydrazyl. The BP complex has been also screened for its antimicrobial activity.
 
Date 2020-09-26T08:20:19Z
2020-09-26T08:20:19Z
2020-09
 
Type Article
 
Identifier 0975-0975(Online); 0376-4710(Print)
http://nopr.niscair.res.in/handle/123456789/55347
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJC-A Vol.59A(09) [September 2020]