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Effect of chrysin endothelial vasodilation on L-NAME induced hypertensive rats

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Title Effect of chrysin endothelial vasodilation on L-NAME induced hypertensive rats
 
Creator Ramanathan, Veerappan
Anandu, Dominic Amalraj Arul
Malarvili, T
 
Subject β-MHC
Chrysin
Fibrinogen
mRNA expression
Nitric oxide
TGF-β
 
Description 572-577
Hypertension is the major risk factor for cardiovascular diseases and stroke and it is one of leading causes of disability and mortality worldwide. The present study was aimed to investigate the antihypertensive and vasodilation properties of chrysin, a naturally occurring flavone, in hypertensive rats. Hypertension was induced using Nω-nitro-l arginine methyl ester (L-NAME; 40 mg/kg BWT/day for 4 weeks) in adult rats and chrysin (25 mg/kg BWT/day) or vehicle was administered for 4 weeks. A siginificant increase of blood pressure and serum fibrinogen along with a significant reduction of bilirubin level were observed in hypertensive rats and these changes were significantly attenuated upon administration of crysin. Further, L-NAME induced increase of tissue levels of mRNAs of β-MHC and TGF-β (in heart) as well as eNOS (in aorta, heart, kidney) were significantly reduced in chrysin treated rats. These results suggest that chrysin has a potential to attenuate impairment of organs (heart and renal) and endothelial function caused by L-NAME induced hypertension.
 
Date 2020-09-30T05:42:10Z
2020-09-30T05:42:10Z
2020-10
 
Type Article
 
Identifier 0975-0959 (Online); 0301-1208 (Print)
http://nopr.niscair.res.in/handle/123456789/55368
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJBB Vol.57(5) [October 2020]