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Ursolic acid prevents cyclophosphamide induced myocardial oxidative tissue damage in wistar rats

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Title Ursolic acid prevents cyclophosphamide induced myocardial oxidative tissue damage in wistar rats
 
Creator Bhatt, Laxit
Singh, Priya
Sebastian, Binu
Joshi, Viraj
 
Subject Cardiomyopathy
Cardioprotection
Chemotherapy adverse effects
Oxidative stress
Phytoconstituents
 
Description 525-532
Herbs and spices of natural origin have been used traditionally for culinary and therapeutic purposes. Ursolic acid, a pentacyclic triterpenoid, is a major component of various foods, herbs and spices utilized in daily life. The purpose of this study was to investigate the cardio-protective action of ursolic acid against cardio-toxicity induced by cyclophosphamide. Animals were randomly divided into control group (1% dimethyl sulfoxide, s.c.), toxic control (Cyclophosphamide 200 mg/kg, i.p.), ursolic acid treated (40 mg/kg, s.c.) and ursolic acid-cyclophosphamide combination treatment. Animals were sacrificed at the end of the treatment period and biochemical, electrocardiographic and histopathological changes were measured. Cyclophosphamide treatment showed marked increase in biomarker enzymes (CKNAC, CKMB, LDH, AST, and ALT), decreased tissue antioxidants (SOD, catalase & GSH), hyperlipidemia (TC, TG) and abnormal electrocardiographic (HR, RR, QRS, QT & PR intervals) and histopathological changes. Ursolic acid treatment restored tissue antioxidants, normalised biochemical and electrocardiographic parameters and prevented structural damage of the myocardium. Findings from this study indicate the protective role of ursolic acid against cardiotoxicity caused by cyclophosphamide.
 
Date 2020-09-30T07:06:53Z
2020-09-30T07:06:53Z
2020-07
 
Type Article
 
Identifier 0975-1068 (Online); 0972-5938 (Print)
http://nopr.niscair.res.in/handle/123456789/55396
 
Language en_US
 
Relation Int. Cl.20: A61K 36/00
 
Rights Publisher: NISCAIR-CSIR, India CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJTK Vol.19(3) [July 2020]