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Biodegradable chitosan-sodium alginate-oleic acid nanocarrier promotes bioavailability and target delivery of lutein in rat model with no toxicity.

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Relation http://ir.cftri.com/14473/
https://doi.org/10.1016/j.foodchem.2020.127195
 
Title Biodegradable chitosan-sodium alginate-oleic acid nanocarrier promotes
bioavailability and target delivery of lutein in rat model with no toxicity.
 
Creator Veeresh, T.
Naveen, J.
Muthukumar, S. P.
Baskaran, V.
 
Subject 14 Carotenoid Chemistry
 
Description Efficient delivery of macular carotenoid lutein to target retinal tissue is possible with enhanced intestinal uptake
remains a major challenge owing to the polarity, sensitivity to light, heat and solubility. In this study, to
overcome such constraints, biodegradable polymers chitosan-sodium alginate-oleic acid based nano-carrier
loaded with lutein (LNCs) was prepared and safety efficacy was examined in vivo. Acute-toxicity of LNCs (0.1, 1,
10 and 100 mg/kg body weight) revealed that the LD50 of LNCs was higher than 100 mg/kg body weight. In
subacute-toxicity of LNCs (1 and 10 mg/kg body weight) revealed no mortality with no morphological and
clinical changes in rats. Histology, haematology and biochemical analysis of urine and plasma confirmed no
toxicity of LNCs compared to control. Post-prandial plasma and tissue (retina) levels of lutein from LNCs were
higher. Results demonstrate increased bioavailability of lutein from LNCs with no toxicity suggests applications
in food and pharma.
 
Date 2020
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14473/1/Food%20Chemistry%20330%20%282020%29%20127195.pdf
Veeresh, T. and Naveen, J. and Muthukumar, S. P. and Baskaran, V. (2020) Biodegradable chitosan-sodium alginate-oleic acid nanocarrier promotes bioavailability and target delivery of lutein in rat model with no toxicity. Food Chemistry, 330. pp. 1-8. ISSN 0308-8146