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<p><strong>Amelioration of cisplatin induced nephrotoxicity by <em>Phyla nodiflora</em> (L.) Greene</strong></p>

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Title Statement <p><strong>Amelioration of cisplatin induced nephrotoxicity by <em>Phyla nodiflora</em> (L.) Greene</strong></p>
 
Added Entry - Uncontrolled Name Sharma, Sonam
Dixit, Priya
Sairam, k
Sahu, Alakh N
 
Uncontrolled Index Term DNA fragmentation assay; Frog fruit; Jal bhuti; Nephroprotective; Rutin
 
Summary, etc. <p class="Abstract" style="text-align: justify;"><em>Phyla nodiflora</em> (Verbenaceae), commonly called frog fruit and locally, <em>jal bhuti</em>, is the traditional folk medicine accepted in the Indian Medicine as well as the Traditional system of Chinese Medicine (TCM) for various treatments viz., urinary disorder, lithiasis, knee joint pain, diuresis and swelling. In the present study, we tried to standardise crude<em> Phyla nodiflora</em> ethanol extract (PNE) using HPTLC and also evaluated its protection against cisplatin induced nephrotoxicity in rats. HPTLC quantification of rutin and fingerprinting profile was performed. Serum kidney toxicity markers, renal tissue antioxidant and pro-inflammatory cytokine levels were assessed followed by DNA fragmentation assay and histopathological examination of renal tissue. Rutin concentration in ethanol extract was found to be 5.35% w/w. In HPTLC fingerprinting 12 peaks with R<sub>f</sub> ranges from 0.08 to 0.86 were confirmed. Serum biochemical parameters, renal tissue antioxidants and pro-inflammatory cytokines levels were found to be restored. The results demonstrated the nephroprotective activity of <em>P. nodiflora</em> ethanol extract (400 mg/kg, p.o.) as evidenced by protection of kidneys from cisplatin induced DNA fragmentation and damage tissue architecture.</p>
 
Publication, Distribution, Etc. Indian Journal of Experimental Biology (IJEB)
2020-09-30 00:00:00
 
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http://op.niscair.res.in/index.php/IJEB/article/view/41205
 
Data Source Entry Indian Journal of Experimental Biology (IJEB); ##issue.vol## 58, ##issue.no## 10 (2020): IJEB [October 2020]
 
Language Note en