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Improvement of vitamin B12 status with Spirulina supplementation in Wistar rats validated through functional and circulatory markers.

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Relation http://ir.cftri.com/14483/
https://doi.org/10.1111/jfbc.13038
 
Title Improvement of vitamin B12 status with Spirulina
supplementation in Wistar rats validated through functional
and circulatory markers.
 
Creator Madhubalaji, C. K.
Rashmi, V.
Chauhan, V. S.
Shylaja, M. Dharmesh
Sarada, R.
 
Subject 01 Algae
04 Vitamins
 
Description Spirulina evaluated as a source of vitamin B12 through the modulation of vitamin B12
deficiency mediated physiological and biochemical changes in experimental animals.
The B12 deficient male weanling Wistar rats were fed with Spirulina‐supplemented
diet for 10 weeks. An increase in urinary methylmalonic acid (22.70 ± 4.08 µmol/
moles of creatinine) and plasma homocysteine (16.55 ± 0.48 µmol/L) levels in the B12
deficient group was observed, while these were equal to control in the Spirulina fed
group (8.71 ± 0.48 µmol/mol of creatinine and 6.88 ± 1.18 µmol/L, respectively). The
vitamin B12 levels in serum (874.27 ± 89.69), plasma (615.53 ± 26.5 pg/ml), kidney
(10.19 ± 1.066 ng/g), and liver tissues (6.37 ± 0.62 ng/g) in the Spirulina fed group
were similar to control. Severe atrophic changes in the testes and altered tissue ar‐
chitecture in lung and spleen as seen in the B12 deficient group were normalized in
the Spirulina fed group. The study validates that Spirulina can improve the vitamin
B12 status.
Practical applications
The present study showed that the supplementation of Spirulina in the diet of vitamin
B12 deficient rats leads to the normalization of vitamin B12 deficiency‐induced circu‐
latory and functional biomarkers along with biochemical and histological changes.
Vegetarian sources for vitamin B12 are limited and the results presented here provide
scientific validation for the use of Spirulina as a potential vegetarian source of bio‐
available vitamin B12
 
Publisher Wiley
 
Date 2020
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14483/1/jfbc.13038.pdf
Madhubalaji, C. K. and Rashmi, V. and Chauhan, V. S. and Shylaja, M. Dharmesh and Sarada, R. (2020) Improvement of vitamin B12 status with Spirulina supplementation in Wistar rats validated through functional and circulatory markers. Journal of Food Biochemistry. ISSN 1745-4514