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Ameliorative effect of flaxseed (Linum usitatissimum) and its protein on ethanol‐induced hepatotoxicity in Wistar rats.

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Relation http://ir.cftri.com/14484/
https://doi.org/10.1111/jfbc.13047
 
Title Ameliorative effect of flaxseed (Linum usitatissimum) and its
protein on ethanol‐induced hepatotoxicity in Wistar rats.
 
Creator Salma, Nida Ume
Muthukumar, S. P.
Jyothi Lakshmi, A.
 
Subject 03 Proteins
01 Oilseeds
 
Description Hepatoprotective effect of flaxseed and its protein on ethanol‐induced hepatotoxic‐
ity in adult Wistar rats was investigated. The rats were divided into eight groups of
which two served as control (group I: Control for AIN‐93M diet groups and group
II: Control for cereal‐pulse diet groups) and six groups received ethanol orally every
day. After 10 days along with ethanol, the rats received AIN‐93M diet (group III);
AIN‐93M diet and commercial hepatoprotective formulation (CHF) (group IV); casein
replaced by flaxseed protein in AIN‐93M diet (group V); cereal‐pulse diet (group VI);
cereal‐pulse diet and CHF (group VII); cereal‐pulse diet containing flaxseed (group
VIII) for four weeks. The flaxseed and its protein significantly prevented the eleva‐
tion of plasma markers of hepatic damage, lowered lipid peroxidation, mitigated
changes in antioxidant enzymes, and suppressed histopathological signs of hepatic
damage. The hepatoprotective effect of flaxseed and its protein was comparable to
CHF. These findings implicate the ameliorative effect of flaxseed and its protein on
ethanol‐induced hepatotoxicity.
Practical applications
Owing to globalization and an increase in earning capacity, alcohol consumption is
becoming a part of social life and gradually transforming to addiction. Binge drinking
is highly prevalent among low socioeconomic status population, which poses severe
risks to health. Alcohol abuse is a public health problem causing three million deaths
annually worldwide. Alcohol consumption is known to be a major cause of liver dam‐
age worldwide and has contributed to 44% of deaths from liver disease. As abstaining
from alcohol is a challenging task, there is an escalating need to formulate potential
hepatoprotective agents to prevent alcohol‐induced hepatic damage. This study in‐
vestigates the efficacy of flaxseed and its protein in conferring protection to the
liver against ethanol‐induced hepatotoxicity. This study also explores the benefits of
incorporating flaxseed in the staple cereal‐pulse diet. Findings of this study suggest
that incorporation of flaxseed or its protein in food formulations can prevent hepato‐
toxicity and improve the overall quality of life among alcoholics.
 
Publisher Wiley
 
Date 2020
 
Type Article
PeerReviewed
 
Format pdf
 
Language en
 
Identifier http://ir.cftri.com/14484/1/jfbc.13047.pdf
Salma, Nida Ume and Muthukumar, S. P. and Jyothi Lakshmi, A. (2020) Ameliorative effect of flaxseed (Linum usitatissimum) and its protein on ethanol‐induced hepatotoxicity in Wistar rats. Journal of Food Biochemistry. ISSN 1745-4514