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An efficient regioselective synthesis of N-alkylated purine-triazole analogues

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Title An efficient regioselective synthesis of N-alkylated purine-triazole analogues
 
Creator Pandit, Chintan
Pandya, Mayank
Jadeja, Yashwantsinh
Gohel, Jyoti
Kapadiya, Khushal
 
Subject 2,6-Dichloropurine
Triazoles
Regioselectivity
 
Description 1225-1233
Nitrogen rich purine adduct (2) was prepared by reaction of 2,6-dichloro purine (1) with hydrazine hydrate was converted to hybrid purine-triazole ring (4) by a simple cyclisation process (con. HCl & methanol) on reaction with 3-phenoxy benzaldehyde. The regioselectivity of synthesized adducts was carried out by simple spectroscopic techniques i.e. IR, 1H NMR & 13C NMR spectra. These studies gave an idea regarding replacement of chlorine out of C-2 or C-6 position. Novelty was introduced by alkyl substation at N-9 position of imidazole ring and at –NH of triazole ring and a series of 4-chloro-5a,6-dihydro-1,6-dialkylated-8-(3-phenoxyphenyl)-1H-[1,2,4]triazolo[3,4-e]purine (5a-5g) hybrids were synthesized.
 
Date 2020-10-05T08:24:31Z
2020-10-05T08:24:31Z
2020-08
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/55441
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJC-B Vol.59B(08) [August 2020]