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Potentiometric determination of oxybutynin hydrochloride in pharmaceutical formulations at modified carbon paste electrodes

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Title Statement Potentiometric determination of oxybutynin hydrochloride in pharmaceutical formulations at modified carbon paste electrodes
 
Added Entry - Uncontrolled Name Mohammad, Marwa Elbadry; Cairo University
Farag, Eman Yousry; Cairo University
Mohammad, Gehad Genidy; Cairo University
 
Uncontrolled Index Term MCPE; ion pairing agents; oxybutynine HCl; pharmaceutical formulation.
 
Summary, etc. <p>A new potentiometric sensitive and selective modified carbon paste (MCPE) electrodes based on phosphotungestic acid (PTA),  sodium tetraphenyl borate (NaTPB),  phosphomolybdic acid (PMA) or ammonium reineckate (RN) ion pairing agents for determination of (Ox.HCl) were developed. The proposed electrodes have a Nernstian slope values of 58.50±0.71, 58.71±1.20, 54.80±1.30 and 59.20±0.70 mV decade-1for electrodes modified with 20, 10, 5 and 10 mg of Ox-TPB (electrode I), Ox-RN (electrode II), Ox-PMA (electrode III) and Ox-PTA (electrode IV) ion pairs, respectively, with a dynamic drug concentration range at 25 (C was 1.0x10-5 - 1.0x10-2 mole L-1 with detection limit of 1.0× 10-5 mol L-1. The response of MCPEs were pH independent in the range 2.0-6.0 with a fast response time of 10 s for electrode I and 12 s for electrodes II-IV. The MCPEs showed a relatively long life time of 36 days. A pure and pharmaceutical formulation of Ox.HCl was quantified using calibration and standard addition methods and the obtained results agreed with that of the official HPLC method. Validation parameters were optimized according to ICH recommendations.</p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section A (IJCA)
2020-10-05 14:32:47
 
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http://op.niscair.res.in/index.php/IJCA/article/view/24915
 
Data Source Entry Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 59, ##issue.no## 3 (2020): INDIAN JOURNAL OF CHEMISTRY- SECTION A
 
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