Record Details

<strong><span lang="EN-US">In silico analysis of the efficacy of some natural compounds as antituberculosis agents</span></strong>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <strong><span lang="EN-US">In silico analysis of the efficacy of some natural compounds as antituberculosis agents</span></strong>
 
Added Entry - Uncontrolled Name kalpana, A. ; Sri Sarada College for Women Salem - 16, Tamilnadu, India.
Jayashree, M ; Sri Sarada College for Women Salem - 16, Tamilnadu, India.
 
Uncontrolled Index Term Anti-TB agents; Molecular docking; PKnB Protein.
 
Summary, etc. Tuberculosis (TB) remains a disease of global importance with approximately two million deaths annually worldwide. Effective treatment of TB has been hampered by the emergence of drug resistant strains of <em>Mycobacterium tuberculosis</em>. Natural products have a proven global history of treating TB diseases and ailments. Available vast reservoir of chemically diverse natural products that provide new templates for drug design can be scrutinized and the most efficient may be chosen by molecular docking studies with the TB proteins. In the present study, an attempt was made to find out a potential natural product to inhibit <em>M. tb - </em>PknB protein by molecular docking method. Docking was performed for around 40 natural products against <em>M. tb </em>– PknB - protein target to determine their potentiality against TB diseases. The anti-TB ability was analysed in terms of Binding Energy. The results indicate that 80% of the natural products (B.E ≥ 7 kcal/mol) under study, exhibit good anti-TB activity. It is known that most of the natural product under study was found to possess greater binding activity than that of the conventional anti-TB drugs.
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section A (IJCA)
2020-10-05 12:32:52
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJCA/article/view/23533
 
Data Source Entry Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 59, ##issue.no## 2 (2020): INDIAN JOURNAL OF CHEMISTRY- SECTION A
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCA/article/download/23533/465473554
http://op.niscair.res.in/index.php/IJCA/article/download/23533/465473704
http://op.niscair.res.in/index.php/IJCA/article/download/23533/465473705
 
Terms Governing Use and Reproduction Note Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2015. The Council of Scientific &amp; Industrial Research, New Delhi.