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<h1><span lang="EN-US">Synthesis </span><span lang="EN-US">and</span><span lang="EN-US"> Characterization <span>of 2-Aminoethylphosphonic Acid-Functionalized Graphene Quantum Dots</span><span>:</span><span> Biological Activity, Antioxidant Activity </span>and Cell Viability</span></h1><br />

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Title Statement <h1><span lang="EN-US">Synthesis </span><span lang="EN-US">and</span><span lang="EN-US"> Characterization <span>of 2-Aminoethylphosphonic Acid-Functionalized Graphene Quantum Dots</span><span>:</span><span> Biological Activity, Antioxidant Activity </span>and Cell Viability</span></h1><br />
 
Added Entry - Uncontrolled Name Yıldız, Mustafa ; Çanakkale Onsekiz Mart University
Yapar, Gönül ; İstanbul Technical University, Department of Chemistry
Şenel, Behiye ; Anadolu University, Department of Pharmaceutical Biotechnology
Demir, Neslihan ; Çanakkale Onsekiz Mart University, Department of Biology
Yıldız, Mustafa ; Çanakkale Onsekiz Mart University, Department of Chemistry
 
Uncontrolled Index Term Synthetic and structural inorganic chemistry; Bio-inorganic chemistry;
N-doped Graphene Quantum Dots, Biological Activity, Antioxidant Activity, MTT, Cell Viability
 
Summary, etc. <p>A facile, environmentally friendly one-step reaction for the preparation of luminescent N-doped graphene quantum dots (GQDs) involving a hydrothermal reaction between citric acid and 2-aminoethylphosphonic acid was designed. Graphene quantum dots were characterized by UV-Vis, FT-IR spectroscopy, transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDX) and dynamic light scattering (DLS). Furthermore, the biological activity of the GQDs was studied. UV-Vis spectroscopy studies of the interactions between the GQDs and calf thymus DNA (CT-DNA) showed that the compound interacts with CT-DNA via intercalative binding. DNA cleavage study showed that the GQDs cleaved DNA oxidatively. In addition, antioxidant activity of N-doped GQDs was measured using the DPPH method. As the concentration of the compound increased, the antioxidant activity also increased. According to cell viability analyses results, the N-doped GQDs showed cell viability (70 %) when the concentration reached 228 μg/mL for A549, 200 μg/mL for MDA-MB-231 and 140 μg/mL for NIH-3T3 cell lines with 24 h incubation.</p><p> </p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section A (IJCA)
2020-10-05 14:32:47
 
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http://op.niscair.res.in/index.php/IJCA/article/view/24449
 
Data Source Entry Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 59, ##issue.no## 3 (2020): INDIAN JOURNAL OF CHEMISTRY- SECTION A
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCA/article/download/24449/465476424
http://op.niscair.res.in/index.php/IJCA/article/download/24449/465487007
http://op.niscair.res.in/index.php/IJCA/article/download/24449/465487008
 
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