<h1><span lang="EN-US">Synthesis </span><span lang="EN-US">and</span><span lang="EN-US"> Characterization <span>of 2-Aminoethylphosphonic Acid-Functionalized Graphene Quantum Dots</span><span>:</span><span> Biological Activity, Antioxidant Activity </span>and Cell Viability</span></h1><br />
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Title Statement |
<h1><span lang="EN-US">Synthesis </span><span lang="EN-US">and</span><span lang="EN-US"> Characterization <span>of 2-Aminoethylphosphonic Acid-Functionalized Graphene Quantum Dots</span><span>:</span><span> Biological Activity, Antioxidant Activity </span>and Cell Viability</span></h1><br /> |
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Added Entry - Uncontrolled Name |
Yıldız, Mustafa ; Çanakkale Onsekiz Mart University Yapar, Gönül ; İstanbul Technical University, Department of Chemistry Şenel, Behiye ; Anadolu University, Department of Pharmaceutical Biotechnology Demir, Neslihan ; Çanakkale Onsekiz Mart University, Department of Biology Yıldız, Mustafa ; Çanakkale Onsekiz Mart University, Department of Chemistry |
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Uncontrolled Index Term |
Synthetic and structural inorganic chemistry; Bio-inorganic chemistry; N-doped Graphene Quantum Dots, Biological Activity, Antioxidant Activity, MTT, Cell Viability |
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Summary, etc. |
<p>A facile, environmentally friendly one-step reaction for the preparation of luminescent N-doped graphene quantum dots (GQDs) involving a hydrothermal reaction between citric acid and 2-aminoethylphosphonic acid was designed. Graphene quantum dots were characterized by UV-Vis, FT-IR spectroscopy, transmission electron microscopy (TEM), energy dispersive X-ray spectroscopy (EDX) and dynamic light scattering (DLS). Furthermore, the biological activity of the GQDs was studied. UV-Vis spectroscopy studies of the interactions between the GQDs and calf thymus DNA (CT-DNA) showed that the compound interacts with CT-DNA via intercalative binding. DNA cleavage study showed that the GQDs cleaved DNA oxidatively. In addition, antioxidant activity of N-doped GQDs was measured using the DPPH method. As the concentration of the compound increased, the antioxidant activity also increased. According to cell viability analyses results, the N-doped GQDs showed cell viability (70 %) when the concentration reached 228 μg/mL for A549, 200 μg/mL for MDA-MB-231 and 140 μg/mL for NIH-3T3 cell lines with 24 h incubation.</p><p> </p> |
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Publication, Distribution, Etc. |
Indian Journal of Chemistry -Section A (IJCA) 2020-10-05 14:32:47 |
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Electronic Location and Access |
application/pdf http://op.niscair.res.in/index.php/IJCA/article/view/24449 |
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Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 59, ##issue.no## 3 (2020): INDIAN JOURNAL OF CHEMISTRY- SECTION A |
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en |
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http://op.niscair.res.in/index.php/IJCA/article/download/24449/465476424 http://op.niscair.res.in/index.php/IJCA/article/download/24449/465487007 http://op.niscair.res.in/index.php/IJCA/article/download/24449/465487008 |
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