<p class="BATitle">Tetrandrine derivatives IVa-IVd: Structural analysis and their inhibition rate against protein tyrosine kinase, and HL60 & A549 cancer cell lines</p>
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Title Statement |
<p class="BATitle">Tetrandrine derivatives IVa-IVd: Structural analysis and their inhibition rate against protein tyrosine kinase, and HL60 & A549 cancer cell lines</p> |
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Added Entry - Uncontrolled Name |
Chen, Chen ; Department of Geriatrics; bDepartment of Endocrinology, Suzhou Ninth People’s Hospital, Jiang su Suzhou 215200, China Lu, Ye ; Department of Geriatrics; bDepartment of Endocrinology, Suzhou Ninth People’s Hospital, Jiang su Suzhou 215200, China |
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Uncontrolled Index Term |
Anticancer; Bromination; CCK-8; FGFR1; PTKs; Suzuki reaction; Tetrandrine |
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Summary, etc. |
<p style="text-align: justify;">Four tetrandrine (TET) derivatives (IVa-IVd) have been synthesized by Suzuki reaction of boronic acid derivatives and 5-bromo-tetrandrine obtained by bromination using tetrandrine as the starting material. The structures are analyzed by <sup>1</sup>H NMR, <sup>13</sup>C NMR and ESI-MS. The inhibition activities of IVa-IVd against HL60 and A549 cancer cell lines have been investigated by CCK-8 assay. The compounds having significant (<em>P</em> <0.040) inhibition activities are secondarily screened by MTT assay. The inhibitory activities of IVa-IVd against protein tyrosine kinases (PTKs) are tested by ELISA. The results show that IVa, IVb and IVc exhibit significant inhibition activities against the two cancer cell lines. The IVb and IVc show highly significant (<em>P</em> <0.001) inhibition activities against fibroblast growth factor receptor 1 (FGFR1).</p> |
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Publication, Distribution, Etc. |
Indian Journal of Chemistry -Section A (IJCA) 2020-10-06 15:05:21 |
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Electronic Location and Access |
application/pdf http://op.niscair.res.in/index.php/IJCA/article/view/41283 |
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Data Source Entry |
Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 59, ##issue.no## 9 (2020): INDIAN JOURNAL OF CHEMISTRY - SECTION A |
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en |
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