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<p class="a"><span style="font-family: "times new roman", times; font-size: small;"><strong>Synthesis and characterization of novel chelation-free Zn(II)-azole complexes: Evaluation of <a name="_Hlk534616852">antibacterial, antioxidant, and DNA binding activity</a></strong></span></p>
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dc |
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| Title Statement |
<p class="a"><span style="font-family: "times new roman", times; font-size: small;"><strong>Synthesis and characterization of novel chelation-free Zn(II)-azole complexes: Evaluation of <a name="_Hlk534616852">antibacterial, antioxidant, and DNA binding activity</a></strong></span></p> |
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| Added Entry - Uncontrolled Name |
Nandanwar, Sondavid K; Pukyong National University Borkar, Shweta B; Pukyong National University Wijaya, Bryan Nathanael; KSA od KAIST Bayarra, Enkhnaran ; KSA od KAIST Piad, Lei Lottice Anne; KSA od KAIST Jin, QiuLi ; KSA od KAIST Tiara, Celine Sheila; KSA od KAIST Kim, Hak Jun ; Pukyong National University Tarte, Naresh H.; KSA od KAIST Korean Science Academy of KAIST and Basic Science Research Program through the National Research Foundation of Korea with funds from the Ministry of Science and ICT (NRF-2015R1A2A2A01005609). |
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| Uncontrolled Index Term |
Bio-inorganic chemistry Antibacterial, Antioxidant, Azole, Chelation-free, DNA binding, Zn(II)-complexes |
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| Summary, etc. |
<span style="font-family: "times new roman", times; font-size: small;">Here, we have synthesized novel chelation-free Zn(II)-complexes (<strong>1</strong>-<strong>3</strong>) [ZnCl<sub>2</sub>L<sub>2</sub>] of monodentate ligands with L= 2-</span>isopropylimidazole<span style="font-family: "times new roman", times; font-size: small;"> (<strong>L1</strong>), 2-</span>methylbenzimidazole<span style="font-family: "times new roman", times; font-size: small;"> (<strong>L2</strong>), and 2-</span>methylbenzoxazole<span style="font-family: "times new roman", times; font-size: small;"> (<strong>L3</strong>) and evaluated their antibacterial, antioxidant and DNA binding activities. The chelation-free properties of these coordination complexes were confirmed by UV-Vis spectroscopy, <sup>1</sup>H-NMR spectroscopy, single X-ray crystallography, and elemental analysis. Complexes <strong>1</strong>-<strong>3 </strong>exhibited substantial antibacterial activity against all antibiotic susceptible bacteria within a concentration range of 100-200 µg/ml while free ligands<strong> L1 </strong>and<strong> L2</strong> exhibited weak antibacterial activity considerably concentration above 200 µg/ml. Also, both complexes <strong>2 </strong>and <strong>3</strong> were twice more active against methicillin-resistant<em> staphylococcus aureus</em> (MRSA<em>) </em>than complex <strong>1</strong>. Furthermore, we found that complexes <strong>1</strong>-<strong>3 </strong>showed DNA binding activity with E. coli plasmid DNA (pDNA) and calf thymus DNA (CT-DNA), which may be a plausible mechanism for their antibacterial activity. We also investigated the antioxidant activity of complexes <strong>1</strong>-<strong>3</strong> and found that complex <strong>2</strong> exhibited potential antioxidant activity compared to complexes <strong>1</strong> and <strong>3</strong>. All these results suggest that the chelation-free Zn(II)-complexes can be the future candidates for more advanced biological studies.</span> |
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| Publication, Distribution, Etc. |
Indian Journal of Chemistry -Section A (IJCA) 2020-10-06 10:36:53 |
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| Electronic Location and Access |
application/pdf http://op.niscair.res.in/index.php/IJCA/article/view/24897 |
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| Data Source Entry |
Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 59, ##issue.no## 5 (2020): INDIAN JOURNAL OF CHEMISTRY- SECTION A |
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| Language Note |
en |
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| Nonspecific Relationship Entry |
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