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<h1><span>MICROWAVE ASSISTED TEMPLATE SYNTHESIS OF METAL BASED EGFR, TRK INHIBITORS, MOLECULAR DOCKING AND IN VITRO BIOLOGICAL STUDIES</span></h1><br />

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Title Statement <h1><span>MICROWAVE ASSISTED TEMPLATE SYNTHESIS OF METAL BASED EGFR, TRK INHIBITORS, MOLECULAR DOCKING AND IN VITRO BIOLOGICAL STUDIES</span></h1><br />
 
Added Entry - Uncontrolled Name Jain, Preeti ; Sharda University
Singh, Vandna ; Gautam Buddha University
Tripathi, Vishwas ; Gautam Buddha University
 
Uncontrolled Index Term Bio-inorganic chemistry,Synthetic and structural inorganic chemistry
Antioxidant , EGFR, microwave method , Molecular docking, Template synthesis
 
Summary, etc. <h1>ABSTRACT: Metal based biologically active compounds were synthesized by microwave assisted template condensation method and characterized by spectro-analytical techniques like molar conductance, UV-Vis, FTIR, Mass spectroscopy and TGA. The metal was arranged in octahedral geometry surrounded by tetradentate ligand framework. The binding affinity of all the metal complexes was evaluated theoretically by molecular docking studies against epidermal growth factor receptor (EGFR) and tyrosine kinase (TRK) receptor molecules which were further verified by in vitro anticancer activity. Complex [Cr(C<sub>16</sub>H<sub>11</sub>N<sub>4</sub>O<sub>2</sub>)(NO<sub>3</sub>)<sub>2</sub>]NO<sub>3 </sub>showed potent <em>in vitro</em> cytotoxicity (IC<sub>50</sub> value 39.5μM) against SCC4 cancer cell line. Antioxidant study was also performed by DPPH assay and significant results were found. [Fe(C<sub>16</sub>H<sub>11</sub>N<sub>4</sub>O<sub>2</sub>)(OAc)<sub>2</sub>]OAc<sub> </sub>and [Cr(C<sub>16</sub>H<sub>11</sub>N<sub>4</sub>O<sub>2</sub>) (OAc)<sub>2</sub>]OAc<sub> </sub>are most effective antioxidants with 78.7% and 76.8% free radical scavenging activity respectively.</h1>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section A (IJCA)
2020-10-06 10:51:12
 
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http://op.niscair.res.in/index.php/IJCA/article/view/26150
 
Data Source Entry Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 59, ##issue.no## 6 (2020): INDIAN JOURNAL OF CHEMISTRY- SECTION A
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCA/article/download/26150/465481458
http://op.niscair.res.in/index.php/IJCA/article/download/26150/465481461
http://op.niscair.res.in/index.php/IJCA/article/download/26150/465481462
 
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