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<p><strong>Study of the physico-chemical properties of vancomycin hydrochloride for determining its potential applications in formulation development</strong></p>

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Title Statement <p><strong>Study of the physico-chemical properties of vancomycin hydrochloride for determining its potential applications in formulation development</strong></p>
 
Added Entry - Uncontrolled Name Saini, Harjas ; Jaypee University of Information Technology
Abbot, Vikrant ; Jaypee University of Information Technology
Bisht, Gopal Singh; Jaypee University of Information Technology
Sharma, Poonam ; Jaypee University of Information Technology
Science and Engineering Research Board (SERB), Government of India
 
Uncontrolled Index Term Thermodynamics
Thermodynamics, acoustic studies, formulation, micellization, interaction studies.
 
Summary, etc. <p>The study of physico-chemical properties of vancomycin hydrochloride is an important parameter in the pre–formulation analysis of a drug. Pre-formulation study provides important information for formulation design or support the need for molecular modification. The main objective of pre-formulation is to develop a stable and an effective drug, with a safe dosage. Therefore properties like specific conductivity, density, viscosity, velocity of sound and specific gravity are determined which further helps in determination of critical micelle concentration (CMC). Other thermodynamic parameters are calculated from CMC like change in entropy, enthalpy and Gibb’s free energy which indicated that formation of micelles is favourable and exothermic in nature. Along with this, thermo-acoustic parameters such as apparent molar volume and apparent molar compressibility have also been determined. These parameters revealed that electrostatic interactions were favourable at lower concentrations of vancomycin hydrochloride whereas hydrophobic interactions were dominant at higher concentrations. All these studies have proven useful in determining the types of interactions occurring in the system. Moreover, a stable concentration of vancomycin hydrochloride can also be determined which may aid in the topical formulation of this drug.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section A (IJCA)
2020-10-06 11:31:09
 
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http://op.niscair.res.in/index.php/IJCA/article/view/28019
 
Data Source Entry Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 59, ##issue.no## 8 (2020): INDIAN JOURNAL OF CHEMISTRY- SECTION A
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCA/article/download/28019/465486619
http://op.niscair.res.in/index.php/IJCA/article/download/28019/465486620
 
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