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<p class="BATitle">Preparation and analysis of sodium carboxymethyl cellulose and its effect on xerophthalmia</p>

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Title Statement <p class="BATitle">Preparation and analysis of sodium carboxymethyl cellulose and its effect on xerophthalmia</p>
 
Added Entry - Uncontrolled Name Wang, Yingshuang ; Department of Ophthalmology, Shenyang Forth People’s Hospital, Liaoning ,China
Huang, Chu-Yan ; Chinese Medicine Section of Dept. of Pharmacy, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, China
Fu, Rongrong ; Department of Ophthalmology, Shenyang Forth People’s Hospital, Liaoning ,China
Zhang, Haiying ; Department of Ophthalmology, Shenyang Forth People’s Hospital, Liaoning ,China
 
Uncontrolled Index Term Sodium carboxymethylcellulose; α-Melanocyte-stimulating hormone; Xerophthalmia; Dry eye model
 
Summary, etc. <p style="text-align: justify;">carboxymethyl cellulose (CMC) has been effectively synthesized with high yield and purity. With the prolongation of time after model establishment, the values of Schirmer<strong> Ⅰ </strong>test (S<strong> Ⅰ </strong>t) and breakup time of tear film gradually decreased. The α-MSH and CMC alone could ameliorate corneal tissue damage and corneal morphological abnormalities in the dry eye to some extent. However, compared with monotherapy, the treatment of α-MSH combined with CMC has a more significant positive effect on the improvement of tear secretion and the stability of tear film in dry eye model in the early stage after modeling. There are significant differences between the model control group and the normal control group at each time point after model establishment (all <em>P</em>&lt;0.01) at 7<sup>th</sup>, 14<sup>th</sup>, 21<sup>th</sup> and 28<sup>th</sup> days after treatment. After 7, 14 and 21 days treatment, the S<strong> Ⅰ </strong>t values in the α-MSH+CMC treatment group were 4.80±0.79, 4.10±0.52 and 4.30±0.86 mm, respectively.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section A (IJCA)
2020-10-06 15:05:21
 
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http://op.niscair.res.in/index.php/IJCA/article/view/41281
 
Data Source Entry Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 59, ##issue.no## 9 (2020): INDIAN JOURNAL OF CHEMISTRY - SECTION A
 
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