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Ursolic acid prevents cyclophosphamide induced myocardial oxidative tissue damage in wistar rats

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Title Statement Ursolic acid prevents cyclophosphamide induced myocardial oxidative tissue damage in wistar rats
 
Added Entry - Uncontrolled Name Bhatt, Laxit ; Biologic Research Toxicology, Sun Pharma Advanced Research Company, Vadodara, India
Singh, Priya ; Biologic Research Toxicology, Sun Pharma Advanced Research Company, Vadodara, India
Sebastian, Binu ; Department of Pharmacology, Shree Devi College of Pharmacy, Mangalore, India
Joshi, Viraj ; Department of Chemical Analysis, Zydus Research Centre, Ahmedabad, India
 
Uncontrolled Index Term Cardiomyopathy; Cardioprotection; Chemotherapy adverse effects; Oxidative stress; Phytoconstituents
 
Summary, etc. <p class="Abstract">Herbs and spices of natural origin have been used traditionally for culinary and therapeutic purposes. Ursolic acid, a pentacyclic triterpenoid, is a major component of various foods, herbs and spices utilized in daily life. The purpose of this study was to investigate the cardio-protective action of ursolic acid against cardio-toxicity induced by cyclophosphamide. Animals were randomly divided into control group (1% dimethyl sulfoxide, s.c.), toxic control (Cyclophosphamide 200 mg/kg, i.p.), ursolic acid treated (40 mg/kg, s.c.) and ursolic acid-cyclophosphamide combination treatment. Animals were sacrificed at the end of the treatment period and biochemical, electrocardiographic and histopathological changes were measured. Cyclophosphamide treatment showed marked increase in biomarker enzymes (CKNAC, CKMB, LDH, AST, and ALT), decreased tissue antioxidants (SOD, catalase &amp; GSH), hyperlipidemia (TC, TG) and abnormal electrocardiographic (HR, RR, QRS, QT &amp; PR intervals) and histopathological changes. Ursolic acid treatment restored tissue antioxidants, normalised biochemical and electrocardiographic parameters and prevented structural damage of the myocardium. Findings from this study indicate the protective role of ursolic acid against cardiotoxicity caused by cyclophosphamide.</p> <br />
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2020-10-07 12:13:07
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJTK/article/view/41451
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 19, ##issue.no## 3 (2020): Indian Journal of Traditional Knowledge
 
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