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<em>In vitro</em> anti-inflammatory and acetylcholinesterase inhibition efficiency of plant extracts from Sinai-Egypt

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Title Statement <em>In vitro</em> anti-inflammatory and acetylcholinesterase inhibition efficiency of plant extracts from Sinai-Egypt
 
Added Entry - Uncontrolled Name Shahat, Abdelaaty A
Ibrahim, Abeer Y
Mohamed, Tarik A
Elshamy, Abdelsamed I
Alqahtani, Ali S
Saleh, Ibrahim A
Hassan, Emad M
Hegazy, Mohamed-Elamir F
 
Uncontrolled Index Term Anti-inflammatory; Acetylcholinesterase; Cyclooxygenase inhibition; Sinai Egyptian wild plants
 
Summary, etc. Ten plant extracts were prepared and tested in <em>in vitro </em>assays against COX-2, COX-1 and acetylcholinesterase with evaluation of their antioxidant properties. The tested extracts exhibited varied anti COX-2 effect and they were superior to celecoxibe (inhibition percentage was 42.67% at 50 µg/mL), reference drug. <em>Lavandula coronopifolia</em> and <em>Scrophularia Libanotica</em> extracts were the efficient inhibitors (100% and 91% at 50 µg/mL respectively). <em>Launaeaspinosa</em> and <em>Pulicaria undulata</em> were the powerful AChE inhibitor (IC<sub>50</sub> values were 16.69 and 29.06 µg/mL, respectively) followed with <em>L. coronopifolia</em> and <em>S.libanotica</em> extracts (IC<sub>50</sub> values were 61.89 and 49.83 µg/mL, respectively) and they were efficient in scavenging superoxide radicals and metal ions, nitric oxide formation inhibition, as well as, lipid peroxide production suppression. <em>L. coronopifolia</em> and <em>S. Libanotica </em>extracts can be introduced as natural cyclooxygenase-2 inhibitors without affecting cyclooxygenase-1 whereas <em>L. spinosa</em> and <em>P. undulata</em> extracts were potent suppressor for AChE with robust antioxidant properties which suggest the possibility of using the four extracts, <em>L. coronopifolia</em>, <em>S. libanotica</em>, <em>L. spinosa</em> and <em>P. undulata</em> as natural agent in treating neurodegenerative disorder.
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2020-10-07 12:13:07
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJTK/article/view/40811
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 19, ##issue.no## 3 (2020): Indian Journal of Traditional Knowledge
 
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