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Bacterial biofilm inhibition activity of ethanolic extract of <em>Hemidesmus indicus</em>

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Title Statement Bacterial biofilm inhibition activity of ethanolic extract of <em>Hemidesmus indicus</em>
 
Added Entry - Uncontrolled Name Girish, Nidhi ; Department of Life Science, Christ (Deemed to be University), Bengaluru 560 029
Mamatha, A ; Department of Pharmacognosy, KLE College of Pharmacy, Bengaluru
 
Uncontrolled Index Term Biofilm inhibition; Drug Resistance; Hemidesmus indicus; Nosocomial infections
 
Summary, etc. <p class="Abstract">Multi-drug resistance is one of the biggest nightmares in the field of healthcare today. Adding on to this, some bacteria like <em>Staphylococcus aureus </em>and <em>Pseudomonas aeruginosa </em>have the ability to form biofilms. These essentially are large colonies of bacteria that are held together by polysaccharides and other biomolecules which in turn facilitate in their adherence to solid substrate – both natural and synthetic. This further creates a life-threatening implication leading to nosocomial infections like pneumonia, Urinary tract infections (UTI), etc. increasing the co-morbidities and mortality of critically-ill patients. The combination of antimicrobial resistance, ability to form biofilms and threat of nosocomial infections calls for a need to investigate newer, safer alternatives.</p> <p class="Abstract">Plant based medicaments have been used for centuries and they are a great alternative to synthetic drugs. In the present study, ethanolic extracts of <em>Hemidesmus indicus</em> was evaluated against clinically-important multi-drug resistant organisms. Percentage biofilm inhibition of plant extracts of <em>Hemidesmus indicus</em> by crystal violet assay method. Triplicate analysis was done and data obtained was statistically interpreted using Microsoft Excel. Alcoholic extracts of <em>Hemidesmus indicus</em> exhibited significant biofilm inhibitory activity against the common bacteria <em>Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus </em>and<em> Bacillus subtilis</em>. Further, isolation of the chief active constituent responsible for Anti-biofilm activity is in process.</p>
 
Publication, Distribution, Etc. Indian Journal of Traditional Knowledge (IJTK)
2020-10-07 12:13:07
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJTK/article/view/41439
 
Data Source Entry Indian Journal of Traditional Knowledge (IJTK); ##issue.vol## 19, ##issue.no## 3 (2020): Indian Journal of Traditional Knowledge
 
Language Note en