Record Details

<p><strong>Synthesis, cytotoxicity, antibacterial activity and molecular modeling study of new mono , homo and heterobimetallic complexes of palladium (II) with some transition </strong><strong>metal ions</strong><strong> containing the ligands </strong><strong><em>N</em></strong><strong>-phenyl-<em>N'</em>-(2-thiazolyl)thiourea and Diphosphines </strong><strong>Ph<sub>2</sub>P(CH<sub>2</sub>)<sub>n</sub>PPh<sub>2</sub>( where n = 1- 3)</strong></p><p><strong><br /></strong></p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p><strong>Synthesis, cytotoxicity, antibacterial activity and molecular modeling study of new mono , homo and heterobimetallic complexes of palladium (II) with some transition </strong><strong>metal ions</strong><strong> containing the ligands </strong><strong><em>N</em></strong><strong>-phenyl-<em>N'</em>-(2-thiazolyl)thiourea and Diphosphines </strong><strong>Ph<sub>2</sub>P(CH<sub>2</sub>)<sub>n</sub>PPh<sub>2</sub>( where n = 1- 3)</strong></p><p><strong><br /></strong></p>
 
Added Entry - Uncontrolled Name Aziz, Nazk mohammed; University of Sulaimani, College of Science
University of Sulaimani, College of Science, Department of Chemistry
 
Uncontrolled Index Term Alkyl diphenylphosphines; Antibacterial activity; Pd(II) complexes; Rhabdomyosarcoma cell line; Thiourea derivatives ligands; Transition metal complexes
 
Summary, etc. <p style="text-align: justify;">The ligand <em>N</em>-phenyl-N'-(2-thiazolyl) thiourea (LH) was prepared from reaction of phenyl isothiocyanate with 2-aminothiazol. Treatment of deporotonated ligand (LH) with sodium tetrachloro palladate(II) afforded [Pd(L)<sub>2</sub>] complex <strong>3</strong>. Reaction of complex 3 with [bis(diphenylphosphino) methane, dppm], [1,2-bis(diphenylphosphino)ethane, dppe] and [1,3-bis(diphenylphosphino)propane, dppp] afforded the mixed ligand complexes of the type [Pd(II)L<sub>2</sub>(Ph<sub>2</sub>P(CH<sub>2</sub>)<sub>n</sub>PPh<sub>2</sub>)], {where n = 1, dppm], n = 2, dppe or n = 3, dppp) <strong>4-6</strong>, respectively.  Further, complexes <strong>4-6</strong> were treated with some transition metal salts to give homo- and heterobimetallic complexes <strong>7-21</strong> of the types: [(Ph<sub>2</sub>P(CH<sub>2</sub>)<sub>n</sub>PPh<sub>2</sub>) Pd (II)-µ-L<sub>2</sub>M'(II)X<sub>m</sub>] and [(Ph<sub>2</sub>P(CH<sub>2</sub>)<sub>n</sub>PPh<sub>2</sub>)Pd(II)-µ-L<sub>2</sub>M'(II)X<sub>m</sub> xH<sub>2</sub>O] ( where  n= 1, 2, or 3 , M' = Pd(II), Ni(II), Mn(II), Co (II) or Cu (II) and X = Cl<sup>-</sup>, m = 2). The ligand and the prepared complexes were characterized by elemental analysis, molar conductivity, magnetic susceptibility, FTIR, UV-Vis, <sup>1</sup>H-<sup>31</sup>P{<sup>1</sup>H} NMR and mass spectroscopy. Some of these complexes were assayed for their inhibition activity against human rhabdomyosarcoma cell line (RMS). Interestingly, compound <strong>19</strong> exhibited a significant cytotoxicity inhibition activity ~ 90% for RMS cell line, suggesting being a new lead in the development of human muscle anticancer agent. All the compounds have been screened for their antibacterial activity against <em>S. aureus</em> and <em>E. coli</em> bacterium.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section A (IJCA)
2020-10-12 16:09:18
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJCA/article/view/23990
 
Data Source Entry Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 58, ##issue.no## 7 (2019): INDIAN JOURNAL OF CHEMISTRY- SECTION A
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCA/article/download/23990/465475012
http://op.niscair.res.in/index.php/IJCA/article/download/23990/465478639
 
Terms Governing Use and Reproduction Note Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2015. The Council of Scientific &amp; Industrial Research, New Delhi.