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Synthesis and antimalarial activity of sulfonamide-attached coumarin-[1,2,3]-triazoles

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Title Synthesis and antimalarial activity of sulfonamide-attached coumarin-[1,2,3]-triazoles
 
Creator Batra, Neha
Rajendran, Vinoth
Wadi, Ishan
Ghosh, Prahlad C
Nath, Mahendra
 
Subject Antimalarial activity
4-hydroxycoumarin
7-hydroxycoumarin
Huisgen [3+2] cycloaddition
Sulfonamides
[1,2,3]-triazoles
 
Description 1545-1555
Drug resistance in malaria parasites is one of the major stumbling blocks hindering the goal of malaria elimination. One of the major strategies to counter drug resistance is the development of new potent antimalarial drugs. In the present study, a series of novel sulfonamide based coumarin-[1,2,3]-triazole conjugates have been synthesized via Huisgen reaction between azidosulfonamides and 4-hydroxy- or 7-hydroxymethylcoumarinoalkynes. All the compounds have been characterized spectroscopically and screened for their in vitro antimalarial activity against P. falciparum 3D7 strain. Out of the twenty five synthesized compounds, four compounds displayed significant activity (IC50
 
Date 2020-10-13T06:14:06Z
2020-10-13T06:14:06Z
2020-10
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/55466
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJC-B Vol.59B(10) [October 2020]