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<p>Kinetic and mechanistic studies of oxidation of chloramphenicol by sodium metaperiodate using Rh(III)-chloride as homogeneous catalyst</p>

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Title Statement <p>Kinetic and mechanistic studies of oxidation of chloramphenicol by sodium metaperiodate using Rh(III)-chloride as homogeneous catalyst</p>
 
Added Entry - Uncontrolled Name SINGH, ASHOK KUMAR; University of Allahabad
Pradhan, Ranju ; University of Allahabad
Srivastava, Jaya ; University of Allahabad
Bala, Ritu Swamini; University of Allahabad
Yadav, Rupam ; University of Allahabad
Rahmani, Shahla ; University of Allahabad
 
Uncontrolled Index Term Kinetics and catalysis
Kinetics, Reaction mechanism, Oxidation, Rhenium, Chloramphenicol
 
Summary, etc. <p>The kinetics of oxidation of an antibiotic drug, chloramphenical(CHP) by NaIO<sub>4 </sub>in the presence of Rh(III) catalyst has been investigated in alkaline medium at 35<sup>0</sup>C. The reaction shows first order kinetics with respect to [IO<sub>4</sub><sup>-</sup>] and [Rh(III)]. The fractional positive order kinetics in [OH<sup>-</sup>] and [CHP] throughout their variations were observed. It was found that ionic strength and dielectric constant of the medium had no effects on the rate of reactions. There is no effect of [Cl<sup>-</sup>] in presence of Rh(III) chloride. The values of rate constants observed at four different temperatures were utilized to calculate various activation parameters. The species [IO<sub>4</sub><sup>-</sup>] and [RhCl<sub>3</sub>(H<sub>2</sub>O)<sub>2</sub>OH]<sup>-</sup> are assumed as the reactive species of NaIO<sub>4</sub> and Rh(III) respectively in alkaline medium. On the basis of kinetic results, spectroscopic information and activation parameters, a suitable mechanism and rate law for the oxidation of CHP has been proposed.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section A (IJCA)
2020-10-19 12:49:45
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJCA/article/view/19552
 
Data Source Entry Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 57, ##issue.no## 4 (2018): INDIAN JOURNAL OF CHEMISTRY- SECTION A
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCA/article/download/19552/59840
http://op.niscair.res.in/index.php/IJCA/article/download/19552/59841
 
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