ICAR Research Data Repository for Knowledge Management
<p class="BBAuthorName"><span lang="EN-IN">Oxovanadium(IV) complexes of polypyridyl bases as photocytotoxic and DNA crosslinking agents </span></p>
Online Publishing @ NISCAIR
View Archive Info| Field | Value | |
| Authentication Code |
dc |
|
| Title Statement |
<p class="BBAuthorName"><span lang="EN-IN">Oxovanadium(IV) complexes of polypyridyl bases as photocytotoxic and DNA crosslinking agents </span></p> |
|
| Added Entry - Uncontrolled Name |
Chakravarty, Akhil R; Dept of Inorganic & Physical Chemistry
Indian Institute of Science Bangalore-560012 Kumar, Arun ; Dept of Inorganic & Physical Chemistry Indian Institute of Science Bangalore-560012 Dixit, Akanksha ; Dept of Biochemistry Indian Institute of Science Bangalore-560012 Banerjee, Samya ; Dept of Inorganic & Physical Chemistry Indian Institute of Science Bangalore-560012 Mukherjee, Sanjoy ; Dept of Inorganic & Physical Chemistry Indian Institute of Science Bangalore-560012 Sahoo, Somarupa ; Dept of Inorganic & Physical Chemistry Indian Institute of Science Bangalore-560012 Karande, Anjali A.; Dept of Biochemistry Indian Institute of Science Bangalore-560012 |
|
| Uncontrolled Index Term |
Bio-inorganic chemistry Bioinorganic chemistry, Photocytotoxicity, Cytotoxicity, DNA crosslinks, DNA cleavage, Vanadium, Polypyridyl bases |
|
| Summary, etc. |
<p>Dichlorooxovanadium(IV) complexes of polypyridyl bases (B), viz., [VO(B)Cl<sub>2</sub>]<sub> </sub>(<strong>1</strong> and <strong>2</strong>) of <em>N,N,N</em>-donor ligands 2-(2-pyridyl)-1,10-phenanthroline (pyphen in <strong>1</strong>) and 3-(pyridin-2-yl)dipyrido[3,2-a:2',3'-c]phenazine (pydppz in <strong>2</strong>) have been prepared, and their anticancer activity studied. The complexes show good solubility in most polar solvent and are <br /> non-electrolytes. They show 1:1 electrolytic property in 20% aqueous DMF, and 1:2 electrolytic character in 20% aqueous DMF upon photo-irradiation with visible light (400–700 nm). Complex <strong>1</strong> shows DNA crosslinking property<strong> </strong>on dissociation of the V-Cl bond(s)<strong> </strong>as ascertained from its DNA melting profile and ethidium bromide displacement assay. The complexes <strong>1</strong> and <strong>2 </strong>are photocytotoxic towards HeLa (IC<sub>50</sub>: 16.9 mM and 0.87 mM respectively) and MCF-7 (IC<sub>50</sub>: 19.5 mM and 1.4 mM respectively) cancer cells, but exhibit less toxicity in normal embryonic fibroblast 3T3 cells with IC<sub>50</sub> values of ~40 and ~25 µM in visible light (400-700 nm) for complexes <strong>1</strong> and <strong>2</strong> respectively.<strong> </strong>Complex <strong>2</strong> also displays light induced plasmid DNA cleavage activity.<strong> </strong>The light-induced cellular damage leads to generation of reactive oxygen species followed by apoptotic cell death.</p> |
|
| Publication, Distribution, Etc. |
Indian Journal of Chemistry -Section A (IJCA) 2020-10-19 12:41:14 |
|
| Electronic Location and Access |
application/pdf http://op.niscair.res.in/index.php/IJCA/article/view/20262 |
|
| Data Source Entry |
Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 57, ##issue.no## 3 (2018): INDIAN JOURNAL OF CHEMISTRY- SECTION A |
|
| Language Note |
en |
|
| Nonspecific Relationship Entry |
http://op.niscair.res.in/index.php/IJCA/article/download/20262/62202 http://op.niscair.res.in/index.php/IJCA/article/download/20262/62282 http://op.niscair.res.in/index.php/IJCA/article/download/20262/62283 http://op.niscair.res.in/index.php/IJCA/article/download/20262/62284 |
|
| Terms Governing Use and Reproduction Note |
Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2015. The Council of Scientific & Industrial Research, New Delhi. |
|