Record Details

<p>Synthesis, DNA binding properties and antibacterial activity of lanthanide complexes with 2-benzoylpyridine isonicotinoylhydrazone</p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p>Synthesis, DNA binding properties and antibacterial activity of lanthanide complexes with 2-benzoylpyridine isonicotinoylhydrazone</p>
 
Added Entry - Uncontrolled Name Reddy, katreddi hussain; Sri Krishnadevraya University
Moksharagni, B ; Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu 515 003 (AP), India
Rishitha, M ; Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu 515 003 (AP), India
 
Uncontrolled Index Term Coordination chemistry, Lanthanum, Cerium, Praseodymium, Neodymium, Samarium, 2-Benzoylpyridine isonicotinoylhydrazone, Hydrazones, DNA binding, and Antibacterial activity
 
Summary, etc. <p>Lanthanide(III) complexes of general formula [Ln(BPINH)<sub>2</sub>(NO<sub>3</sub>)](NO<sub>3</sub>)<sub>2</sub> (where, Ln = La, Ce, Pr, Nd, Sm, and BPINH = 2-benzoylpyridine isonicotinoylhydrazone) have been synthesized under mild reaction conditions with excellent yields. The structure of BPINH is determined using single crystal X-ray diffraction studies. The lanthanide complexes have been characterized by elemental analysis, molar conductance and various spectral techniques such as FT-IR, UV-vis, IR and <sup>1</sup>H-NMR spectroscopies. Electrolytic nature of complexes is investigated by conductivity studies. The spectral data suggest that the ligand acts as a neutral tridentate NNO-donor system. Electrochemical behaviour of metal complexes is investigated by using cyclic voltammetry. The complexes undergo quasi-reversible one-electron reduction. Absorption titration studies reveal that these complexes are avid binders (<em>K</em><sub>b</sub> = 10<sup>5</sup>) to calf-thymus DNA. The antibacterial activities of the ligand and its lanthanide complexes have been screened <em>in vitro</em> against, <em>Bacillus subtilis </em>(MTCC-441) and <em>Staphylococcus aurous </em>(MTCC-3160) which are gram positive and <em>Salmonella typhi </em>(MTCC-735) and <em>Escherichia coli </em>(MTCC-1652) which are gram negative organisms. It has been observed the lanthanide complexes show more pronounced activity than the ligand (BPINH).</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section A (IJCA)
2020-10-23 12:45:04
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJCA/article/view/13568
 
Data Source Entry Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 56, ##issue.no## 2 (2017): INDIAN JOURNAL OF CHEMISTRY - SECTION A
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCA/article/download/13568/39722
http://op.niscair.res.in/index.php/IJCA/article/download/13568/39805
 
Terms Governing Use and Reproduction Note Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2015. The Council of Scientific &amp; Industrial Research, New Delhi.