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The tomato receptor CuRe1 senses a cell wall protein to identify Cuscuta as a pathogen

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Title The tomato receptor CuRe1 senses a cell wall protein to identify Cuscuta as a pathogen
 
Creator Hegenauer, Volker
Slaby, Peter
Körner, Max
Bruckmüller, Julien-Alexander
Burggraf, Ronja
Albert, Isabell
Kaiser, Bettina
Löffelhardt, Birgit
Droste-Borel, Irina
Sklenar, Jan
Menke, Frank L. H.
Maček, Boris
Ranjan, Aashish
Sinha, Neelima
Nürnberger, Thorsten
Felix, Georg
Krause, Kirsten
Stahl, Mark
Albert, Markus
 
Subject Biotic
Pattern recognition receptors in plants
tomato receptor
Cuscuta
pathogen
 
Description Accepted date: 28 September 2020
Parasitic plants of the genus Cuscuta penetrate shoots of host plants with haustoria and build a connection to the host vasculature to exhaust water, solutes and carbohydrates. Such infections usually stay unrecognized by the host and lead to harmful host plant damage. Here, we show a molecular mechanism of how plants can sense parasitic Cuscuta. We isolated an 11 kDa protein of the parasite cell wall and identified it as a glycine-rich protein (GRP). This GRP, as well as its minimal peptide epitope Crip21, serve as a pathogen-associated molecular pattern and specifically bind and activate a membrane-bound immune receptor of tomato, the Cuscuta Receptor 1 (CuRe1), leading to defense responses in resistant hosts. These findings provide the initial steps to understand the resistance mechanisms against parasitic plants and further offer great potential for protecting crops by engineering resistance against parasitic plants.
The work of M.A. was funded by the German Research Foundation (DFG AL 1426/1-2
and 1-3; AL 1426/4-1). K.K. and J.-A.B. were supported by grant 16-TF-KK from the
Tromsø Research Foundation. The work of N.S. was supported by USDA-NIFA (2013-
02345). We thank Farid El Kasmi from the ZMBP Tübingen for kindly providing us the
modified pGWB660 including the tagRFP. We would further like to thank Rory Pruitt
for constructive criticism and critical reading of the manuscript
 
Date 2020-10-23T10:39:00Z
2020-10-23T10:39:00Z
2020
 
Type Article
 
Identifier Nature Communications, 11(1): 5299
2041-1723
https://doi.org/10.1038/s41467-020-19147-4
https://www.nature.com/articles/s41467-020-19147-4
http://223.31.159.10:8080/jspui/handle/123456789/1119
 
Language en_US
 
Format application/pdf
 
Publisher Springer Nature Publishing AG