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<p>Synthesis and biological evaluation of novel phosphonyl thiazolo pyrazoles</p>

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Title Statement <p>Synthesis and biological evaluation of novel phosphonyl thiazolo pyrazoles</p>
 
Added Entry - Uncontrolled Name Srinivas, Avula ; Department of Chemistry, Vaagdevi Degree & PG College, Kishanpura, Warangal 506 001, India
Karthik, Pulluri ; Department of Chemistry, Vaagdevi Degree & PG College, Kishanpura, Warangal 506 001, India
Sunitha, Malladi ; Jayamukhi Institute of Technological Sciences, Chennaraopet Mandal, Narsampet, Nekkonda Rd, Arshanapally 506 332, India
Reddy, K Vasumathi ; Department of Zoology, Vaagdevi Degree & PG College, Kishanpura, Warangal 506 001, India
 
Uncontrolled Index Term Phosponylpyrazoles, Bestmenohira reagent, click reaction, Knovenagel condensation, cyclisation, nematicidal activity
 
Summary, etc. <p>A series of novel dimethyl 7-((2S,3S)-3-((1-(4-chlorophenyl)-1<em>H</em>-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2<em>H</em>-pyran-2-yl)-4-(4-fluorophenyl)-9-oxo-8-phenyl-6-thia-1,2,8-triazaspiro[4.4]non-2-en-3-ylphosphonate <strong>11a-g</strong> have been synthesized by the reaction of chalcone derivatives of (<em>E</em>)-5-benzylidene-2-((2S,3S)-3-((1-(4-chlorophenyl)-1<em>H</em>-1,2,3-triazol-4-yl)methoxy)-3,6-dihydro-2<em>H</em>-pyran-2-yl)-3-phenylthiazolidin-4-one <strong>10a-g</strong> with Bestmen Ohira reagent. The chemical structures of newly synthesized compounds have been elucidated by IR, NMR, MS and elemental analysis. The compounds <strong>11a-g</strong> have been evaluated for their nematicidal activity against <em>Dietylenchus myceliophagus</em> and <em>Caenorhabditis elegans</em>. Compound <strong>11b</strong>, <strong>11c</strong>, <strong>11g</strong> and <strong>11f</strong> show appreciable nematicidal activity.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2020-08-28 12:49:07
 
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http://op.niscair.res.in/index.php/IJCB/article/view/42526
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 59, ##issue.no## 6 (2020): INDIAN JOURNAL OF CHEMISTRY - SECTION B
 
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