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<p>Manglicolous lichen <em>Parmotrema tinctorum </em>(Despr. ex Nyl.) Hale: Isolation, characterization and biological evaluation</p>

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Title Statement <p>Manglicolous lichen <em>Parmotrema tinctorum </em>(Despr. ex Nyl.) Hale: Isolation, characterization and biological evaluation</p>
 
Added Entry - Uncontrolled Name Tatipamula, Vinay Bharadwaj; Institute of Research and Development, Duy Tan University, Da Nang 550000, Vietnam
Kethab, Alekhya ; Pharmaceutical Chemistry Department, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, India
 
Uncontrolled Index Term Manglicolous lichen, toxicity studies, antioxidant, anticancer, Sulforhodamine B assay
 
Summary, etc. <p>The chemical examination of the ethanolic extract of manglicolous lichen <em>Parmotrema tinctorum</em> <strong>(Pt-Et)</strong> has resulted in isolation of six known metabolites, <em>i</em>.<em>e</em>., methyl-β-orcinolcarboxylate <strong>(1)</strong>, isolecanoric acid <strong>(2)</strong>, methyl-2,6-dihydroxy-4-methylbenzoate <strong>(3)</strong>, haematommic acid <strong>(4)</strong>, ethyl haematommate <strong>(5)</strong>, and atranorin <strong>(6)</strong>. All the isolates <strong>1-6</strong> and <strong>Pt-Et</strong> have been screened against DPPH and superoxide free radicals, six different cancer cell lines (MDA-MB-231, SW620, HeLa, FADU, A549, SKOV3) and one normal human cell line (NHME). Compound <strong>3</strong> exhibits prominent inhibition of superoxide free radical, which appears to be better than that of the standard (ascorbic acid) with an IC<sub>50</sub> value of 26.0 µg/mL. From the SRB assay results, it is observed that the better IC<sub>50</sub> values have been obtained from <strong>4</strong> and <strong>5</strong> on HeLa, FADU, and A549, respectively. In addition, all the tested samples show low cell lysis on NHME, which indicates low toxicity. Consequently, the outcomes revealed that <em>P. tinctorum</em> could be a new source to treat oxidative stress and cancer. This work is the first report of antioxidant and cytotoxicity studies on the isolated metabolites <strong>1-6</strong>.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2020-08-28 12:49:07
 
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http://op.niscair.res.in/index.php/IJCB/article/view/42524
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 59, ##issue.no## 6 (2020): INDIAN JOURNAL OF CHEMISTRY - SECTION B
 
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