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Antioxidant and anticholinergic properties of <em>Citrus sinensis</em> (L.) Osbeck (Rutaceae) essential oil in mice hippocampus

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Title Statement Antioxidant and anticholinergic properties of <em>Citrus sinensis</em> (L.) Osbeck (Rutaceae) essential oil in mice hippocampus
 
Added Entry - Uncontrolled Name C M, Feitosa ; Federal University of Piauí, Department of Chemistry, Petrônio Portela Campus, Ininga, Teresina, Piauí, 64.049-550, Brazil
M F K, Cardoso ; Natural Products of Laboratory and Research in Experimental Neurochemistry Federal University of Piauí, 64.049-550, Teresina, Piauí, Brazil
L S G, Oliveira ; Natural Products of Laboratory and Research in Experimental Neurochemistry Federal University of Piauí, 64.049-550, Teresina, Piauí, Brazil
J, Figueredo ; Federal University of Piauí, Department of Chemistry, Petrônio Portela Campus, Ininga, Teresina, Piauí, 64.049-550, Brazil
C H S, Melo ; Federal University of Piauí, Department of Chemistry, Petrônio Portela Campus, Ininga, Teresina, Piauí, 64.049-550, Brazil
K, Rashed ; Pharmacognosy Department, National Research Centre, 33 El-Bohouth st.-Dokki, Giza, P.O.12622, Egypt
 
Uncontrolled Index Term Antiacetylcholinesterase activity; Antioxidant activity; Citrus sinensis; Essential oil
 
Summary, etc. <p style="text-align: justify;">This study evaluated anti-acetylcholinesterase and antioxidant potentials in mice hippocampus treated with essential oils (EO) of <em>Citrus sinensis</em> (L.) Osbeck (orange)<em> in vitro</em> and <em>in vivo</em>. The acetylcholinesterase (AChE) activity was evaluated by using an adapted spectrophotometric method by Ellman after administration (30 consecutive days) in albino mice at doses of 50.00 mg/kg (EO 50), 100.00 mg/kg (EO 100) and 200.00 mg/kg (EO 200). The results showed that there was a significant decrease on enzymatic activity of AChE in mice hippocampus treated with essential oil of <em>C. sinensis</em> at doses of 50.00 mg/kg (vehicle= 9.89±0.19, OE 50= 2.63±0.21) [<em>P </em>&lt;0.05], 100.00 mg/kg (vehicle= 9.89±0.19, EO 100= 1.65±0.15) [<em>P </em>&lt;0.05] and 200.00 mg/kg (vehicle= 9.89±0.19, EO 200= 2.38±0.12) [<em>P </em>&lt;0.05] when compared with vehicle group (0.05% Tween 80 dissolved in saline 0.9%). Concerning antioxidant activity, there was a significant reduction (<em>P </em>&lt;0.05) of 20% on lipid peroxidation level in mice hippocampus treated with a dose of 200.00 mg/kg. The results obtained from the current studies showed that the essential oil of <em>C. sinensis</em> has considerable antioxidant and activity and inhibitory effect on AChE.</p>
 
Publication, Distribution, Etc. Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]
2020-11-04 16:14:39
 
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http://op.niscair.res.in/index.php/IJNPR/article/view/24672
 
Data Source Entry Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)]; ##issue.vol## 11, ##issue.no## 3 (2020): September 2020
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJNPR/article/download/24672/465506117
 
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