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<p>An eco-safe and solvent-free approach for clean and one-pot synthesis of <br /> 3,4-dihydropyrimidin-2-(1<em>H</em>)-one/thione derivatives using <em>Zn(OAc)<sub>2</sub>.2H<sub>2</sub></em>O <br /> as an environmental friendly, readily and efficient catalyst</p>

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Title Statement <p>An eco-safe and solvent-free approach for clean and one-pot synthesis of <br /> 3,4-dihydropyrimidin-2-(1<em>H</em>)-one/thione derivatives using <em>Zn(OAc)<sub>2</sub>.2H<sub>2</sub></em>O <br /> as an environmental friendly, readily and efficient catalyst</p>
 
Added Entry - Uncontrolled Name Mohamadpour, Farzaneh ; School of Engineering, Apadana Institute of Higher Education, Shiraz, Iran
 
Uncontrolled Index Term 3,4-Dihydropyrimidin-2-(1H)-ones/thiones derivatives, zinc acetate dihydrate (Zn(OAc)2.2H2O), Biginelli condensation reaction, solvent-free conditions, environment friendly, economical synthesis
 
Summary, etc. <p class="Abstract">An environmental friendly, economical and clean Biginelli approach in presence of readily available <em>zinc</em><em> </em>acetate dihydrate<em> </em><em>(Zn(OAc)<sub>2</sub>.2H<sub>2</sub></em>O) to access biologically active 3,4-dihydropyrimidin-2-(1<em>H</em>)-ones/thiones derivatives <em>via</em> one-pot, three-component reaction of β-keto esters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehye derivatives) and urea or thiourea in high to excellent yields has been studied. This solvent-free procedure is sustainable and advantageous compared to conventional methods due to short reaction times, one-pot procedure, easy handling, efficient, environmentally benign nature, low-cost and non-toxic catalyst, eco-friendly, ready availability of starting materials and no requirement of chromatographic purification. The products have been characterized by melting points and <sup>1</sup>H NMR spectroscopy.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2020-11-04 15:59:01
 
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http://op.niscair.res.in/index.php/IJCB/article/view/42572
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 59, ##issue.no## 7 (2020): INDIAN JOURNAL OF CHEMISTRY - SECTION B
 
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