Record Details

<p>Asymmetric synthesis of 2,4,5- substituted prolines through 1,3-dipolar addition reaction of N-arylidene menthyl esters of α-aminoacid with methyl acrylate</p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p>Asymmetric synthesis of 2,4,5- substituted prolines through 1,3-dipolar addition reaction of N-arylidene menthyl esters of α-aminoacid with methyl acrylate</p>
 
Added Entry - Uncontrolled Name Panday, Sharad Kumar; Department of Applied Chemistry, Faculty of Engineering and Technology M. J. P. Rohilkhand University, Bareilly 243 006, India
Prasad, Jagdish ; Department of Applied Chemistry, Faculty of Engineering and Technology M. J. P. Rohilkhand University, Bareilly 243 006, India
Kumar, Munish ; Department of Applied Chemistry, Faculty of Engineering and Technology M. J. P. Rohilkhand University, Bareilly 243 006, India
 
Uncontrolled Index Term Asymmetric synthesis, α-amino acid, Schiff base, 1,3-dipolar addition, 2,4,5-substituted prolines
 
Summary, etc. <p>Proline and its derivatives constitute the important organic entities as organocatalyst, ACE inhibitors, bioactive molecules/intermediates to bioactive molecules as well as components of various natural products <em>e</em>.<em>g</em>. Kainic acid, <br /> (-)-domoic acid, <em>etc</em>. Due to its wide range of utility extensive studies have been made for the synthesis of 2, 3, 4 or 5 substituted prolines. One pot synthesis of 2,4,5-substituted prolines through 1,3-dipolar addition of various amino acids with homochiral acrylate has also been carried out successfully. Herein we wish to report the 1,3-dipolar addition of Schiff bases, where chiral auxiliary has been introduced in the Schiff bases and 1,3dipolar addition with methyl acrylate leading to the synthesis of 2(S),4(S),5(R)-substituted prolines has been achieved successfully.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2020-11-04 15:59:01
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJCB/article/view/42578
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 59, ##issue.no## 7 (2020): INDIAN JOURNAL OF CHEMISTRY - SECTION B
 
Language Note en
 
Terms Governing Use and Reproduction Note Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2015. The Council of Scientific &amp; Industrial Research, New Delhi.