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<p>In vitro anti-leishmanial activities and structure-activity relationship analysis of new antimony(III) complexes</p><p> </p>

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Title Statement <p>In vitro anti-leishmanial activities and structure-activity relationship analysis of new antimony(III) complexes</p><p> </p>
 
Added Entry - Uncontrolled Name Tunç, Turgay ; Ahi Evran University
Ertabaklar, Hatice ; Department of Parasitology, Medicine Faculty, Adnan Menderes University, Aydın 09010, Turkey
Karacan, Nurcan ; Department of Chemistry, Science Faculty, Gazi University, Ankara 06500, Turkey
This work has been supported in part by the Scientific and Technological Research Council of Turkey (TUBITAK Project no: 212T089).
 
Uncontrolled Index Term Antimony(III) complexes, Anti-leishmanial activity, Structure-activity relationship
 
Summary, etc. <p><strong> </strong></p> <p style="text-align: justify;">New fourteen antimony(III) complexes of general formula [SbL<sub>n</sub>Cl<sub>3</sub>] (where n= 1 or 2, L =2-aminopyridine, 5-methyl-2-aminopyridine, 2-aminopyrimidine, 4,6-dimethoxy-2-aminopyrimidine, 2-benzyl-2-thiopseudeourea,2-guanidinobenzimidazole, 2-amino-5-thiol-4,6-dimethoxypyrimidine, 2-amino-5-(1H-tetrazol-5-ylthio)-4,6-dimethoxypyrimidine, N-2-pyrimidine, 2-piperidinecarboxamide, N-2-pyrimidine, 2-pyrrolidinecarboxamide, 2-amino-5-(1H-tetrazol-5-iltiyo)-4,6-dimethoxypyrimidine-2-pyrrolidinecarboxamide and N-2-pyrimidine, 5-chloro-2-thiophenecarboxamide<strong>, </strong>N-2-benzothiazol-2-pyrrolidinecarboxaamide, N,N-(1,2-phenyl)dipyrrolidine-2-carboxamide) have been synthesized and their anti-leishmanial activity have been assessed in vitro against <em>Leishmania tropica</em> promastigotes. The best complex, Sb(2-guanidinobenzimidazole)Cl<sub>3</sub> is demostrated 3.16% growth inhibition at a concentration of 31.25 μg/mL. In general, antimony(III) complexes containing pyrimidine ligands has showed higher anti-leishmanial activity than antimony(III) complexes bearing pyridine ligands, and electron-donating substituents decrease the anti-leishmanial activity. All complexes have been optimised with DFT/B3LYP/LANL2DZ method in the gas phase. Several descriptors are tested to find a quantitative correlation between anti-leishmanial activity and structural properties of the complexes by best multiple linear regression method. Good correlations are obtained with minimum net atomic charge for a C atom and maximum bond order of a Cl atom. The developed QSAR equation is internally validated.</p> <p><strong> </strong></p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section A (IJCA)
2020-11-05 10:09:35
 
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http://op.niscair.res.in/index.php/IJCA/article/view/27269
 
Data Source Entry Indian Journal of Chemistry -Section A (IJCA); ##issue.vol## 59, ##issue.no## 11 (2020): INDIAN JOURNAL OF CHEMISTRY - SECTION A
 
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Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCA/article/download/27269/465498654
http://op.niscair.res.in/index.php/IJCA/article/download/27269/465498655
 
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