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Effect of ursolic acid on olanzapine induced weight gain in Sprague Dawley rats

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Title Effect of ursolic acid on olanzapine induced weight gain in Sprague Dawley rats
 
Creator Parasuraman, Subramani
Zhen, Khor Ming
Wen, Lim Ee
Hean, Chin Kean
Balamurugan, Subramani
Christapher, Parayil Varghese
Banik, Urmila
 
Subject Antipsychotics
Depression
Schizophrenia
 
Description 760-769
Antipsychotics used in the treatment of schizophrenia are known to cause weight gain. Phytoconstituents are used to manage such drug-induced weight gain. Ursolic acid is a pentacyclic triterpenoid commonly present in many herbs and fruits which are used in daily life. The effect of ursolic acid on antipsychotic-induced weight gain is not clear. Here, we investigated the effect of ursolic acid on olanzapine-induced weight gain in rats. Sprague-Dawley (SD) rats were divided into six different groups viz., normal control, olanzapine control, betahistine (10 mg/kg), and ursolic acid 10, 20 and 40 mg/kg treated groups. All the drugs were administered once daily for 28 days orally. Except for the normal control group, all other animals were treated with olanzapine 4 mg/kg intraperitoneally to induce weight gain. During the experiment, animal’s behaviour variations were monitored at regular intervals. At the end of the experiment, blood sample was collected from all the experimental animals for biochemical analysis. Part of the brain, liver, heart, lung and kidney tissues were excised from the sacrificed animals and preserved in neutral formalin for histopathological studies. Ursolic acid showed a significant reduction in olanzapine-induced body weight gain on the rats. Increase in locomotor activity was also observed with the treatment of ursolic acid. Compared to ursolic acid, betahistine showed better tolerance against olanzapine-induced body weight gain.
 
Date 2020-10-29T10:58:11Z
2020-10-29T10:58:11Z
2020-11
 
Type Article
 
Identifier 0975-1009 (Online); 0019-5189 (Print)
http://nopr.niscair.res.in/handle/123456789/55583
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJEB Vol.58(11) [November 2020]