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Synthesis of triazine linked pyrazole heterocyclics by conventional heating and microwave irradiative cyclocondensation and evaluation of antitubercular and antimicrobial potential

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Title Synthesis of triazine linked pyrazole heterocyclics by conventional heating and microwave irradiative cyclocondensation and evaluation of antitubercular and antimicrobial potential
 
Creator Deohate, Pradip P
Mulani, Roshani S
 
Subject Triazine-pyrazole
Conventional
Microwave
Antitubercular
Antimicrobial
 
Description 1707-1712
The synthesis of (4-benzylideneamino-6-methyl-[1,3,5]-triazin-2-yl)-(5-methyl-2-substituted phenyl/H-pyrazol-3-yl)-amines and (4-benzylideneamino-6-methyl-[1,3,5]-triazin-2-yl)-(5-methyl-2-substituted benzoyl/isonicotinoyl/cinnamoyl-pyrazol-3-yl)-amines by conventional heating and microwave irradiative cyclocondensation have been achieved by the cyclisation of N-(4-benzylideneamino-6-methyl-[1,3,5]-triazin-2-yl)-3-oxo butyramide with substituted hydrazines and acid hydrazides. The required butyramide has been synthesized by the reaction of 2,4-diamino-6-methyl-[1,3,5]-triazine with benzaldehyde followed by the condensation with ethyl acetoacetate. Structural elucidation of synthesized compounds has been performed by IR, 1H NMR and mass spectral studies besides chemical transformation and elemental analysis. The title compounds have been evaluated for their antitubercular and antimicrobial potential against some selected microorganisms to establish the structure activity relationship.
 
Date 2020-11-09T10:13:22Z
2020-11-09T10:13:22Z
2020-11
 
Type Article
 
Identifier 0975-0983(Online); 0376-4699(Print)
http://nopr.niscair.res.in/handle/123456789/55646
 
Language en_US
 
Rights CC Attribution-Noncommercial-No Derivative Works 2.5 India
 
Publisher NISCAIR-CSIR, India
 
Source IJC-B Vol.59B(11) [November 2020]