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<p>Synthesis and biological evaluation of novel indolyl-dihydropyridin-3-carboxylate, dihydro[1,2,4]triazol[1,5]pyridin-3-carboxylate and carbohydrazide derivatives</p>

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Title Statement <p>Synthesis and biological evaluation of novel indolyl-dihydropyridin-3-carboxylate, dihydro[1,2,4]triazol[1,5]pyridin-3-carboxylate and carbohydrazide derivatives</p>
 
Added Entry - Uncontrolled Name Walmik, Prabhaker ; Department of Post-Graduate Studies and Research in Chemistry, Sahyadri Science College (Kuvempu University), Shivamogga 577 203, India
UGC-BSR-Start up Grant (N0.30-374/2019)
 
Uncontrolled Index Term Indole, dihydropyridine, dihydro[1,2,4]triazol[1,5]pyridine, antimicrobial, antioxidant, antitubercular activity
 
Summary, etc. <p>The present study anticipates the development of novel antioxidant, antimicrobial and antitubercular drugs by using the indole scaffold. Novel indole derivatives, <strong>(4a-c),</strong> <strong>(5a-c)</strong> and <strong>(6a-i)</strong> have been prepared. The structures of all these unknown compounds have been confirmed with the help of elemental analysis, IR, <sup>1</sup>H &amp; <sup>13</sup>C NMR and mass spectral data. All these previously unknown synthesized compounds screened for their antioxidant, antimicrobial and antitubercular activities. Compound <strong>5a </strong>exhibited good RSA 76.58 %, IC<sub>50 </sub>value<sub> </sub>&lt;25 µg/mL. Compound <strong>5a</strong> exhibited higher absorbance 0.691nm, at concentration 100 µg/mL. Compound <strong>6a</strong> showed good metal chelating activity (64.10 %) at a concentration 100 µg/mL. Compound <strong>6a</strong> showed potent activity against<em> </em><em>S</em><em>.</em><em> aureus </em>and<em> P.</em><em> aeruginosa</em><em>.</em> Compounds <strong>4a</strong> and <strong>5a</strong> showed promising antitubercular activity MIC 6.25 µg/mL. Compound <strong>6a</strong> showed excellent activity (MIC= 3.125 µg/mL) against                  <em>M. tuberculosis</em> H37Rv, than the standards pyrazinamide (MIC= 3.125) and Streptomycin (6.25 µg/mL).</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2020-11-09 10:52:30
 
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http://op.niscair.res.in/index.php/IJCB/article/view/28026
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 59, ##issue.no## 8 (2020): Indian Journal of Chemistry Section - B (IJCB)
 
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