Record Details

<p><em>In silico</em> and <em>in vitro </em>validation of some benzimidazole derivatives as adenosine deaminase inhibitors</p>

Online Publishing @ NISCAIR

View Archive Info
 
 
Field Value
 
Authentication Code dc
 
Title Statement <p><em>In silico</em> and <em>in vitro </em>validation of some benzimidazole derivatives as adenosine deaminase inhibitors</p>
 
Added Entry - Uncontrolled Name Kumar G, Arun ; Department of Biotechnology and Microbiology, Kannur University, Thalassery Campus, Kannur 670 661, India
C S, Sharanya ; Department of Biotechnology and Microbiology, Kannur University, Thalassery Campus, Kannur 670 661, India
J, Abhithaj ; Department of Biotechnology and Microbiology, Kannur University, Thalassery Campus, Kannur 670 661, India
C, Sadasivan ; Department of Biotechnology and Microbiology, Kannur University, Thalassery Campus, Kannur 670 661, India
Indian Council of Medical Research
 
Uncontrolled Index Term Adenosine deaminase, benzimidazole, inhibition assay, fluorescence spectroscopy, molecular dynamics
 
Summary, etc. <p class="Abstract"><span lang="EN-GB">Benzimidazole nucleus considered as an important scaffold for developing drug candidates against a wide spectrum of diseases. Adenosine deaminase (ADA), an enzyme present in purine metabolic pathway, has a significant role in inflammatory and malignant diseases and hence it is considered as a major target for drug development. The present study investigates ADA inhibitory potential of selected benzimidazole derivatives by using <em>in silico</em> and <em>in vitro</em> methods. Molecular docking and dynamics simulations have been carried out to identify potential ADA activesite binders from benzimidazole derivatives. Compounds having strong binding affinities were selected for enzyme inhibition assays and fluorescent binding studies. The results showed that the pyridinyl and butyl derivatives of benzimidazole possess significant ADA inhibitory potential.The study proposes these compounds can be used as potent candidates for developing ADA inhibitor drugs. </span></p><br />
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2020-11-09 10:52:30
 
Electronic Location and Access application/pdf
http://op.niscair.res.in/index.php/IJCB/article/view/27972
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 59, ##issue.no## 8 (2020): Indian Journal of Chemistry Section - B (IJCB)
 
Language Note en
 
Nonspecific Relationship Entry http://op.niscair.res.in/index.php/IJCB/article/download/27972/465486379
http://op.niscair.res.in/index.php/IJCB/article/download/27972/465486380
 
Terms Governing Use and Reproduction Note Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India© 2015. The Council of Scientific &amp; Industrial Research, New Delhi.