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<p>An efficient regioselective synthesis of <em>N</em>-alkylated purine-triazole analogues</p>

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Title Statement <p>An efficient regioselective synthesis of <em>N</em>-alkylated purine-triazole analogues</p>
 
Added Entry - Uncontrolled Name Pandit, Chintan ; Bio-Research and Characterization Centre, School of Science, Department of Chemistry, R K University, Rajkot, India
Pandya, Mayank ; Bio-Research and Characterization Centre, School of Science, Department of Chemistry, R K University, Rajkot, India
Kapadiya, Khushal ; Bio-Research and Characterization Centre, School of Science, Department of Chemistry, R K University, Rajkot, India
Jadeja, Yashwantsinh ; Department of Chemistry, Marwadi University, Rajkot, India
Gohel, Jyoti ; Chemical Research Laboratory, Department of Chemistry, Saurashtra University, Rajkot, India
 
Uncontrolled Index Term 2,6-Dichloropurine, triazoles, regioselectivity
 
Summary, etc. <p>Nitrogen rich purine adduct <strong>(2)</strong> was prepared by reaction of 2,6-dichloro purine <strong>(1)</strong> with hydrazine hydrate was converted to hybrid purine-triazole ring <strong>(4)</strong> by a simple cyclisation process (con. HCl &amp; methanol) on reaction with <br /> 3-phenoxy benzaldehyde. The regioselectivity of synthesized adducts was carried out by simple spectroscopic techniques <em>i.e.</em> IR, <sup>1</sup>H NMR &amp; <sup>13</sup>C NMR spectra. These studies gave an idea regarding replacement of chlorine out of C-2 or C-6 position. Novelty was introduced by alkyl substation at <em>N</em>-9 position of imidazole ring and at –NH of triazole ring and a series of <strong><em>4-chloro-5a</em>,<em>6-dihydro-1</em>,<em>6-dialkylated-8-(3-phenoxyphenyl)-1H-[1</em>,<em>2</em>,<em>4]triazolo[3</em>,<em>4-e]purine </em>(5a-5g) </strong>hybrids were synthesized.</p>
 
Publication, Distribution, Etc. Indian Journal of Chemistry -Section B (IJC-B)
2020-11-09 10:52:30
 
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http://op.niscair.res.in/index.php/IJCB/article/view/42744
 
Data Source Entry Indian Journal of Chemistry -Section B (IJC-B); ##issue.vol## 59, ##issue.no## 8 (2020): Indian Journal of Chemistry Section - B (IJCB)
 
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